AIMC Topic: Circadian Rhythm

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Rhythm profiling using COFE reveals multi-omic circadian rhythms in human cancers in vivo.

PLoS biology
The study of ubiquitous circadian rhythms in human physiology requires regular measurements across time. Repeated sampling of the different internal tissues that house circadian clocks is both practically and ethically infeasible. Here, we present a ...

CircaKB: a comprehensive knowledgebase of circadian genes across multiple species.

Nucleic acids research
Circadian rhythms, which are the natural cycles that dictate various physiological processes over a 24-h period, have been increasingly recognized as important in the management and treatment of various human diseases. However, the lack of sufficient...

Interpreting machine learning models to investigate circadian regulation and facilitate exploration of clock function.

Proceedings of the National Academy of Sciences of the United States of America
The circadian clock is an important adaptation to life on Earth. Here, we use machine learning to predict complex, temporal, and circadian gene expression patterns in Most significantly, we classify circadian genes using DNA sequence features genera...

Classification of Infectious and Noninfectious Diseases Using Artificial Neural Networks from 24-Hour Continuous Tympanic Temperature Data of Patients with Undifferentiated Fever.

Critical reviews in biomedical engineering
Fever is one of the major clinical symptoms of undifferentiated fever cases. Early diagnosis of undifferentiated fever is a challenging task for the physician. The aim of this study was to classify infectious and noninfectious diseases from 24-hour c...

[Effect of Acupuncture at Points in Heel Vessel for Circadian Genes of 1 and 2 mRNAs in the Suprachiasmatic Nucleus in Insomnia Rats].

Zhen ci yan jiu = Acupuncture research
OBJECTIVE: To investigate the influence and mechanism of acupuncture at the points in Heel Vessel for the circadian clock genes of Period () 1 and 2 mRNAs in the suprachiasmatic nucleus (SCN) in insomnia rats.

What time is it? Deep learning approaches for circadian rhythms.

Bioinformatics (Oxford, England)
MOTIVATION: Circadian rhythms date back to the origins of life, are found in virtually every species and every cell, and play fundamental roles in functions ranging from metabolism to cognition. Modern high-throughput technologies allow the measureme...