AIMC Topic: Circadian Rhythm
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Diagnostic performance of actigraphy in Alzheimer's disease using a machine learning classifier - a cross-sectional memory clinic study.
Alzheimer's research & therapy
May 21, 2025
BACKGROUND: Movement patterns, activity levels and circadian rhythm are altered in Alzheimer's disease (AD) and can be assessed by actigraphy using wearable sensors. We aimed to determine the diagnostic performance of actigraphy in AD in a memory cli...
A circadian behavioral analysis suite for real-time classification of daily rhythms in complex behaviors.
Cell reports methods
May 19, 2025
Long-term analysis of animal behavior has been limited by reliance on real-time sensors or manual scoring. Existing machine learning tools can automate analysis but often fail under variable conditions or ignore temporal dynamics. We developed a scal...
Prognostic value of circadian rhythm-associated genes in breast cancer.
World journal of surgical oncology
May 14, 2025
OBJECTIVE: Breast cancer (BC) remains the most prevalent malignancy among women. Clinical evidence indicates that genetic variations related to circadian rhythms, as well as the timing of therapeutic interventions, influence the response to radiation...
Machine learning-based prediction of restless legs syndrome using digital phenotypes from wearables and smartphone data.
Scientific reports
May 10, 2025
Restless legs syndrome (RLS) is a relatively common neurosensory disorder that causes an irresistible urge for leg movement. RLS causes sleep disturbances and reduced quality of life, but accurate diagnosis remains challenging owing to the reliance o...
Rhythm profiling using COFE reveals multi-omic circadian rhythms in human cancers in vivo.
PLoS biology
May 1, 2025
The study of ubiquitous circadian rhythms in human physiology requires regular measurements across time. Repeated sampling of the different internal tissues that house circadian clocks is both practically and ethically infeasible. Here, we present a ...
CircaKB: a comprehensive knowledgebase of circadian genes across multiple species.
Nucleic acids research
Jan 6, 2025
Circadian rhythms, which are the natural cycles that dictate various physiological processes over a 24-h period, have been increasingly recognized as important in the management and treatment of various human diseases. However, the lack of sufficient...
Interpreting machine learning models to investigate circadian regulation and facilitate exploration of clock function.
Proceedings of the National Academy of Sciences of the United States of America
Aug 10, 2021
The circadian clock is an important adaptation to life on Earth. Here, we use machine learning to predict complex, temporal, and circadian gene expression patterns in Most significantly, we classify circadian genes using DNA sequence features genera...
Classification of Infectious and Noninfectious Diseases Using Artificial Neural Networks from 24-Hour Continuous Tympanic Temperature Data of Patients with Undifferentiated Fever.
Critical reviews in biomedical engineering
Jan 1, 2018
Fever is one of the major clinical symptoms of undifferentiated fever cases. Early diagnosis of undifferentiated fever is a challenging task for the physician. The aim of this study was to classify infectious and noninfectious diseases from 24-hour c...
[Effect of Acupuncture at Points in Heel Vessel for Circadian Genes of 1 and 2 mRNAs in the Suprachiasmatic Nucleus in Insomnia Rats].
Zhen ci yan jiu = Acupuncture research
Dec 25, 2017
OBJECTIVE: To investigate the influence and mechanism of acupuncture at the points in Heel Vessel for the circadian clock genes of Period () 1 and 2 mRNAs in the suprachiasmatic nucleus (SCN) in insomnia rats.
What time is it? Deep learning approaches for circadian rhythms.
Bioinformatics (Oxford, England)
Jun 15, 2016
MOTIVATION: Circadian rhythms date back to the origins of life, are found in virtually every species and every cell, and play fundamental roles in functions ranging from metabolism to cognition. Modern high-throughput technologies allow the measureme...
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