SUMMARY: Disease ontology (DO) annotates human genes in the context of disease. DO is important annotation in translating molecular findings from high-throughput data to clinical relevance. DOSE is an R package providing semantic similarity computati...
BACKGROUND: Fuzzy logic can help reduce the difficulties faced by computational systems to represent and simulate the reasoning and the style adopted by radiologists in the process of medical image analysis. The study described in this paper consists...
UNLABELLED: Protein function prediction (PFP) is an automated function prediction method that predicts Gene Ontology (GO) annotations for a protein sequence using distantly related sequences and contextual associations of GO terms. Extended similarit...
BACKGROUND AND OBJECTIVE: The importance of data standards when integrating clinical research data has been recognized. The common data element (CDE) is a consensus-based data element for data harmonization and sharing between clinical researchers, i...
OBJECTIVE: To standardize and objectivize treatment response assessment in oncology, guidelines have been proposed that are driven by radiological measurements, which are typically communicated in free-text reports defying automated processing. We st...
Machine learning, particularly kernel methods, has been demonstrated as a promising new tool to tackle the challenges imposed by today's explosive data growth in genomics. They provide a practical and principled approach to learning how a large numbe...
This paper considers microarray gene expression data clustering using a novel two stage meta-heuristic algorithm based on the concept of α-planes in general type-2 fuzzy sets. The main aim of this research is to present a powerful data clustering app...
Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disorder that has serious physical and mental health implications. It is evident that disruptions to mitochondrial function have a considerable impact on the survival, activation, and di...
Liver cancer (LC) is the second leading cause of cancer-related deaths globally, yet the molecular mechanisms linking its progression with associated risk factors (RFs) remain poorly understood. To address this, we developed an integrative multi-stag...
Genomic imprinting is an epigenetic occurrence that results in the expression of alleles specific to the parent of origin, plays pivotal roles in plant development, stress adaptation, and agronomic trait regulation. While imprinting has been intensiv...
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