Coronary artery disease (CAD) commonly occurs and elevates the risk of cardiovascular events and mortality in chronic kidney disease (CKD) patients. The underlying pathogenesis of CKD-related CAD is believed to be closely linked to inflammatory respo...
International journal of biological macromolecules
Jun 1, 2025
The N6-methyladenosine(m6A) modification plays crucial regulatory roles in various biological processes including gene expression regulation, RNA stability, splicing, and translation. Accurate prediction of m6A modification sites is essential for und...
The modeling of protein-protein interactions (PPIs) has been revolutionized by artificial intelligence, with deep learning and end-to-end frameworks such as AlphaFold and its derivatives now dominating the field. This review surveys the current compu...
The pharmaceutical industry faces persistent challenges in developing effective treatments for complex diseases, creating an urgent need for innovative approaches to accelerate drug discovery. A pivotal factor in this process is the accurate predicti...
BACKGROUND: The relationship between autophagy and the progression of hepatocellular carcinoma (HCC) is notably substantial, yet the underlying mechanisms remain incompletely elucidated. Our objective is to construct a predictive model, thereby provi...
MOTIVATION: Accurately predicting drug-target interactions (DTIs) is critical for accelerating drug discovery, repositioning, and development. Traditional experimental methods are often expensive and time-consuming, emphasizing the need for efficient...
International journal of biological macromolecules
Jun 1, 2025
BACKGROUND: Diabetic foot ulcers (DFU) represent one of the most severe complications of diabetes mellitus and are closely associated with persistent hyperglycemia. Endoplasmic reticulum stress response proteins play critical roles in the development...
BACKGROUND AND OBJECTIVE: The elucidation of candidate genes is fundamental to comprehending intricate diseases, vital for early diagnosis, personalized treatment, and drug discovery. Traditional Disease Gene Identification methods encounter limitati...
Psoriasis is a common immune - mediated skin disease, the pathogenesis of which is not completely elucidated. Environmental factors are key to its onset and progression. Bisphenol A (BPA) is a ubiquitous environmental pollutant that endangers human h...
International journal of biological macromolecules
Jun 1, 2025
The pathogenesis of kidney cancer is not fully understood, so there is an urgent need to identify new biomarkers to improve diagnosis and treatment. The study identified KIF4A, TOP2A and ASPM as novel protein biomarkers for renal cancer and explored ...
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