We introduce the CDRP (Concatenated Diagnostic-Relapse Prognostic) architecture for multi-task deep learning that incorporates a clinical algorithm, e.g., a risk stratification schema to improve prognostic profiling. We present the first application ...
BACKGROUND: The Allen Mouse Brain Atlas allows study of the brain's molecular anatomy at cellular scale, for thousands genes. To fully leverage this resource, one must register histological images of brain tissue - a task made challenging by the brai...
The lancet. Gastroenterology & hepatology
Dec 6, 2018
Computer-aided diagnosis offers a promising solution to reduce variation in colonoscopy performance. Pooled miss rates for polyps are as high as 22%, and associated interval colorectal cancers after colonoscopy are of concern. Optical biopsy, whereby...
IEEE journal of biomedical and health informatics
Dec 5, 2018
BACKGROUND: Deep learning has been recently applied to a multitude of computer vision and medical image analysis problems. Although recent research efforts have improved the state of the art, most of the methods cannot be easily accessed, compared or...
AIMS: To evaluate if a deep learning algorithm can be trained to identify tumour-infiltrating lymphocytes (TILs) in tissue samples of testicular germ cell tumours and to assess whether the TIL counts correlate with relapse status of the patient.
AMIA ... Annual Symposium proceedings. AMIA Symposium
Dec 5, 2018
We propose a frame-based natural language processing (NLP) method that extracts cancer-related information from clinical narratives. We focus on three frames: cancer diagnosis, cancer therapeutic procedure, and tumor description. We utilize a deep le...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Dec 5, 2018
Accurate image-based medical diagnosis relies upon adequate image quality and clarity. This has important implications for clinical diagnosis, and for emerging methods such as telemedicine and computer-based image analysis. In this study, we trained ...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Dec 5, 2018
Parkinson's Disease (PD) is one of the most prevalent neurodegenerative diseases that affects tens of millions of Americans. PD is highly progressive and heterogeneous. Quite a few studies have been conducted in recent years on predictive or disease ...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Dec 5, 2018
There has been an increasing interest in developing deep learning methods to recognize clinical concepts from narrative clinical text. Recently, several studies have reported that Recurrent Neural Networks (RNNs) outperformed traditional machine lear...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Dec 5, 2018
Detecting negation in biomedical texts entails the automatic identification of negation cues (e.g. "never", "not", "no longer") as well as the scope of these cues. When medical concepts or terms are identified within the scope of a negation cue, thei...
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