AIMC Topic: Diabetes Mellitus, Type 1

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Research Gaps, Challenges, and Opportunities in Automated Insulin Delivery Systems.

Journal of diabetes science and technology
BACKGROUND: Since the discovery of the life-saving hormone insulin in 1921 by Dr Frederick Banting in 1921, there have been many critical discoveries and technical breakthroughs that have enabled people living with type 1 diabetes (T1D) to live longe...

Personalized machine learning models for noninvasive hypoglycemia detection in people with type 1 diabetes using a smartwatch: Insights into feature importance during waking and sleeping times.

PloS one
Hypoglycemia is a major challenge for people with diabetes. Therefore, glycemic monitoring is an important aspect of diabetes management. However, current methods such as finger pricking and continuous glucose monitoring systems (CGMS) are invasive, ...

Intervention through an intelligent technological platform for socio-emotional development and health promotion in adolescents with Type 1 Diabetes Mellitus (emoTICare): A study protocol for randomized controlled trial.

PloS one
BACKGROUND: During adolescence, individuals face various challenges that require adequate psychosocial and emotional adjustment. Additionally, the presence of a chronic illness during this stage, such as Type 1 Diabetes Mellitus (T1DM), introduces ad...

Insulin resistance in type 1 diabetes is a key modulator of platelet hyperreactivity.

Diabetologia
AIMS/HYPOTHESIS: Individuals with type 1 diabetes are at increased cardiovascular risk, particularly in the presence of insulin resistance. A prothrombotic environment is believed to contribute to this risk but thrombotic pathways in type 1 diabetes ...

Modeling the number of new cases of childhood type 1 diabetes using Poisson regression and machine learning methods; a case study in Saudi Arabia.

PloS one
Diabetes mellitus stands out as one of the most prevalent chronic conditions affecting pediatric populations. The escalating incidence of childhood type 1 diabetes (T1D) globally is a matter of increasing concern. Developing an effective model that l...

Personalized glucose forecasting for people with type 1 diabetes using large language models.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Type 1 Diabetes (T1D) is an autoimmune disease that requires exogenous insulin via Multiple Daily Injections (MDIs) or subcutaneous pumps to maintain targeted glucose levels. Despite the advances in Continuous Glucose Monito...

Personalized Blood Glucose Forecasting From Limited CGM Data Using Incrementally Retrained LSTM.

IEEE transactions on bio-medical engineering
For people with Type 1 diabetes (T1D), accurate blood glucose (BG) forecasting is crucial for the effective delivery of insulin by Artificial Pancreas (AP) systems. Deep learning frameworks like Long Short-Term-Memory (LSTM) have been widely used to ...

Identification and validation of endoplasmic reticulum stress-related diagnostic biomarkers for type 1 diabetic cardiomyopathy based on bioinformatics and machine learning.

Frontiers in endocrinology
BACKGROUND: Diabetic cardiomyopathy (DC) is a serious complication in patients with type 1 diabetes mellitus and has become a growing public health problem worldwide. There is evidence that endoplasmic reticulum stress (ERS) is involved in the pathog...

Disease diagnostics using machine learning of B cell and T cell receptor sequences.

Science (New York, N.Y.)
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system's own record of antigen exposures encoded by receptors on B cells and T ce...

Deep learning-based prediction of autoimmune diseases.

Scientific reports
Autoimmune Diseases are a complex group of diseases caused by the immune system mistakenly attacking body tissues. Their etiology involves multiple factors such as genetics, environmental factors, and abnormalities in immune cells, making prediction ...