AIMC Topic: Diabetes Mellitus, Type 2

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Diabetic retinopathy as the primary predictor of mild cognitive impairment in type 2 diabetes: Insights from machine learning models.

PloS one
Mild cognitive impairment (MCI) is a significant and increasingly recognized problem in individuals with type 2 diabetes mellitus (T2DM). This study aims to develop a machine-learning model to predict MCI in patients with T2DMThe dataset was obtained...

Development and validation of a machine learning model for cardiovascular disease risk prediction in type 2 diabetes patients.

Scientific reports
Patients with type 2 diabetes mellitus (T2DM) have a significantly higher risk of cardiovascular disease (CVD) compared to the general population. Accurately predicting this risk is crucial for developing personalized treatment plans and public healt...

Ratio of haemorrhagic area to retinal area as a novel indicator for AI-based screening of diabetic retinopathy in type 2 diabetes: a community-based cross-sectional study.

BMJ open
BACKGROUND: The application of artificial intelligence (AI) technology in the screening of diabetic retinopathy (DR) has made significant strides. However, there remains a lack of comprehensive validation and evaluation of AI-derived quantitative ind...

Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning.

eLife
Diabetes affects >10% of adults worldwide and is caused by impaired production or response to insulin, resulting in chronic hyperglycemia. Pancreatic islet β-cells are the sole source of endogenous insulin, and our understanding of β-cell dysfunction...

Intestinal bacteria translocation promotes β-cell dysfunction in DIO mice.

Scientific reports
Awareness of the intestinal microflora involved in insulin resistance and type 2 diabetes (T2DM) has now become more evident. However, direct mechanical insight is required to illustrate the contribution of intestinal microflora in the disease progre...

FTIR spectroscopy imaging coupled with machine learning reveals biochemical changes in the brains of diabetic mice.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Diabetic encephalopathy is a progressive complication of type 2 diabetes, yet its region-specific biochemical changes remain unclear. In this study, we applied Fourier Transform Infrared Microspectroscopy (FTIRM) to assess metabolic alterations in th...

Predicting fracture toughness of human cortical bone from donors with and without type 2 diabetes using Raman spectroscopy and machine learning.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Type 2 diabetes mellitus (T2DM) is associated with increased skeletal fragility, yet standard clinical assessments often fail to detect diabetes-induced changes in bone quality. Raman spectroscopy (RS), a label-free and non-destructive technique, off...

Urinary Complement proteome strongly linked to diabetic kidney disease progression.

Nature communications
Diabetic kidney disease (DKD) progression is not well understood. Using high-throughput proteomics, biostatistical, pathway and machine learning tools, we examine the urinary Complement proteome in two prospective cohorts with type 1 or 2 diabetes an...

Exhaled gas biomarkers: a non-invasive approach for distinguishing diabetes and its complications.

The Analyst
Exhaled gas detection offers a safe, convenient, and non-invasive clinical diagnostic method for preventing the progression of diabetes to complications. In this study, gas chromatography-mass spectrometry (GC-MS) analysis and statistical methods wer...

Association between air pollution and type II diabetes in Italy from clinical data and population-weighted exposure at the municipality level.

Scientific reports
A growing body of literature supports the association between ambient particulate pollution and the risk of type 2 diabetes (T2DM). Both issues are particularly relevant in Italy. This study investigates the relationship between T2DM and exposure to ...