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Diabetes Mellitus, Type 2

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Deciphering the role of metal ion transport-related genes in T2D pathogenesis and immune cell infiltration via scRNA-seq and machine learning.

Frontiers in immunology
INTRODUCTION: Type 2 diabetes (T2D) is a complex metabolic disorder with significant global health implications. Understanding the molecular mechanisms underlying T2D is crucial for developing effective therapeutic strategies. This study employs sing...

Optimising test intervals for individuals with type 2 diabetes: A machine learning approach.

PloS one
BACKGROUND: Chronic disease monitoring programs often adopt a one-size-fits-all approach that does not consider variation in need, potentially leading to excessive or insufficient support for patients at different risk levels. Machine learning (ML) d...

Predicting Type 2 diabetes onset age using machine learning: A case study in KSA.

PloS one
The rising prevalence of Type 2 Diabetes (T2D) in Saudi Arabia presents significant healthcare challenges. Estimating the age at onset of T2D can aid early interventions, potentially reducing complications due to late diagnoses. This study, conducted...

Predicting Diabetic Retinopathy Using a Machine Learning Approach Informed by Whole-Exome Sequencing Studies.

Biomedical and environmental sciences : BES
OBJECTIVE: To establish and validate a novel diabetic retinopathy (DR) risk-prediction model using a whole-exome sequencing (WES)-based machine learning (ML) method.

Diabetic peripheral neuropathy detection of type 2 diabetes using machine learning from TCM features: a cross-sectional study.

BMC medical informatics and decision making
AIMS: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus. Early identification of individuals at high risk of DPN is essential for successful early intervention. Traditional Chinese medicine (TCM) tongue diagnos...

PNL: a software to build polygenic risk scores using a super learner approach based on PairNet, a Convolutional Neural Network.

Bioinformatics (Oxford, England)
SUMMARY: Polygenic risk scores (PRSs) hold promise for early disease diagnosis and personalized treatment, but their overall discriminative power remains limited for many diseases in the general population. As a result, numerous novel PRS modeling te...

Association Between Aortic Imaging Features and Impaired Glucose Metabolism: A Deep Learning Population Phenotyping Approach.

Academic radiology
RATIONALE AND OBJECTIVES: Type 2 diabetes is a known risk factor for vascular disease with an impact on the aorta. The aim of this study was to develop a deep learning framework for quantification of aortic phenotypes from magnetic resonance imaging ...

GARNN: An interpretable graph attentive recurrent neural network for predicting blood glucose levels via multivariate time series.

Neural networks : the official journal of the International Neural Network Society
Accurate prediction of future blood glucose (BG) levels can effectively improve BG management for people living with type 1 or 2 diabetes, thereby reducing complications and improving quality of life. The state of the art of BG prediction has been ac...

Development and Validation of a Machine Learning Algorithm for Predicting Diabetes Retinopathy in Patients With Type 2 Diabetes: Algorithm Development Study.

JMIR medical informatics
BACKGROUND: Diabetic retinopathy (DR) is the leading cause of preventable blindness worldwide. Machine learning (ML) systems can enhance DR in community-based screening. However, predictive power models for usability and performance are still being d...

Machine learning reveals connections between preclinical type 2 diabetes subtypes and brain health.

Brain : a journal of neurology
Previous research has established type 2 diabetes mellitus as a significant risk factor for various disorders, adversely impacting human health. While evidence increasingly links type 2 diabetes to cognitive impairment and brain disorders, understand...