AIMC Topic: Drug Screening Assays, Antitumor

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Chemical characterization, antioxidant, genotoxic and in vitro cytotoxic activity assessment of Juniperus communis var. saxatilis.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Dec 26, 2017
Chemical composition and antioxidative, genotoxic and cytotoxic potential of essential oil (EO) and post-distillation waste (PDW) of Serbian Juniperus communis L. var. saxatilis Pall. was studied in human lung carcinoma (A549) and normal lung fibrobl...
Rats G2 Phase Apoptosis Juniperus Male Cell Line Humans Cell Line, Tumor Antineoplastic Agents, Phytogenic Doxorubicin Female Chromatography, Liquid Antioxidants Mutagens Animals Drug Screening Assays, Antitumor Plant Extracts Cell Division Tandem Mass Spectrometry Gas Chromatography-Mass Spectrometry
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5-fluorouracil combined with cisplatin and mitomycin C as an optimized regimen for hyperthermic intraperitoneal chemotherapy in gastric cancer.

Journal of surgical oncology Dec 19, 2017
BACKGROUND AND OBJECTIVES: Optimized drug regimens for hyperthermic intraperitoneal chemotherapy (HIPEC) have not been standardized completely in patients with advanced gastric cancer (GC). We evaluated an optimized anti-tumor protocol comprising 5-f...
Stomach Neoplasms Cell Line, Tumor Antineoplastic Combined Chemotherapy Protocols Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Cisplatin Fluorouracil Mitomycin Humans Hyperthermia, Induced Cell Growth Processes
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Effects of salinity on bacterial communities, Maillard reactions, isoflavone composition, antioxidation and antiproliferation in Korean fermented soybean paste (doenjang).

Food chemistry Oct 26, 2017
The purpose of this study was to investigate bacterial communities and health-benefit-related parameters in doenjang prepared with various brine concentrations (8, 12, 16, and 20%). Phenolic, flavonoid, melanoidin and isoflavone contents, antioxidati...
Maillard Reaction Soy Foods Isoflavones Antioxidants Polymers Cell Proliferation Hydrogen-Ion Concentration Phenols Fermentation Drug Screening Assays, Antitumor Fermented Foods Humans Bacteria Lactobacillus HT29 Cells Microbial Consortia
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Anticancer and anti-inflammatory activities of girinimbine isolated from .

Drug design, development and therapy Dec 28, 2016
Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a...
Tumor Cells, Cultured Apoptosis Murraya Lipopolysaccharides Dose-Response Relationship, Drug Zebrafish Cell Survival Alkaloids Animals Antineoplastic Agents, Phytogenic HT29 Cells Mice Drug Screening Assays, Antitumor Nitric Oxide Humans Structure-Activity Relationship Cell Proliferation Cytokines Anti-Inflammatory Agents, Non-Steroidal
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Predicting target proteins for drug candidate compounds based on drug-induced gene expression data in a chemical structure-independent manner.

BMC medical genomics Dec 18, 2015
BACKGROUND: Phenotype-based high-throughput screening is a useful technique for identifying drug candidate compounds that have a desired phenotype. However, the molecular mechanisms of the hit compounds remain unknown, and substantial effort is requi...
Neoplasms Antineoplastic Agents Transcriptome Gene Expression Regulation, Neoplastic Drug Screening Assays, Antitumor MCF-7 Cells Structure-Activity Relationship HL-60 Cells Humans Machine Learning
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Low-cost robotic manipulation of live microtissues for cancer drug testing.

Science advances May 16, 2025
The scarcity of human biopsies available for drug testing is a paramount challenge for developing therapeutics, disease models, and personalized treatments. Microtechnologies that combine the microscale manipulation of tissues and fluids offer the ex...
Antineoplastic Agents Drug Screening Assays, Antitumor Robotics Lab-On-A-Chip Devices Humans Neoplasms
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A Novel Effective Models for Identifying BRCA Patients and Optimizing Clinical Treatments.

Anti-cancer agents in medicinal chemistry Jan 1, 2025
OBJECTIVE: This study aimed to develop an effective model that identifies high-risk breast cancer (BRCA) patients and optimizes clinical treatments.
Prognosis Female Breast Neoplasms Antineoplastic Agents Humans Machine Learning Cell Proliferation Drug Screening Assays, Antitumor
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PySmash: Python package and individual executable program for representative substructure generation and application.

Briefings in bioinformatics Sep 2, 2021
BACKGROUND: Substructure screening is widely applied to evaluate the molecular potency and ADMET properties of compounds in drug discovery pipelines, and it can also be used to interpret QSAR models for the design of new compounds with desirable phys...
Carcinogens Humans Carcinogenicity Tests Software Machine Learning Drug Discovery Computational Biology Drug Screening Assays, Antitumor
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Anticancer drug synergy prediction in understudied tissues using transfer learning.

Journal of the American Medical Informatics Association : JAMIA Jan 15, 2021
OBJECTIVE: Drug combination screening has advantages in identifying cancer treatment options with higher efficacy without degradation in terms of safety. A key challenge is that the accumulated number of observations in in-vitro drug responses varies...
Humans Drug Screening Assays, Antitumor Drug Synergism Cell Line, Tumor Computational Biology Models, Theoretical Neural Networks, Computer Drug Combinations Machine Learning Antineoplastic Agents
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Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model.

Journal of enzyme inhibition and medicinal chemistry Dec 1, 2020
Cyclin-dependent kinase 2 (CDK2) is the family of Ser/Thr protein kinases that has emerged as a highly selective with low toxic cancer therapy target. A multistage virtual screening method combined by SVM, protein-ligand interaction fingerprints (PLI...
Cell Proliferation Support Vector Machine Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Molecular Docking Simulation Antineoplastic Agents HCT116 Cells Protein Kinase Inhibitors Cyclin-Dependent Kinase 2 Structure-Activity Relationship A549 Cells Molecular Structure Drug Evaluation, Preclinical
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