AIMC Topic: Drug Screening Assays, Antitumor

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Chemical findings and in vitro biological studies to uphold the use of Ficus exasperata Vahl leaf and stem bark.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Dec 27, 2017
Ficus exasperata Vahl, commonly known as sandpaper, is a terrestrial Afro-tropical tree used in popular medicine. Despite the existence of some works on the biological activities of this species, its chemical composition is still poorly known. The ai...
Superoxides Plant Leaves Ficus Drug Screening Assays, Antitumor Spectrophotometry, Ultraviolet Plant Bark Functional Food Chromatography, High Pressure Liquid Nitric Oxide Humans Hypoglycemic Agents Reproducibility of Results Dose-Response Relationship, Drug Cell Line, Tumor Spectrometry, Mass, Electrospray Ionization Dietary Supplements Plant Extracts Plant Stems Inhibitory Concentration 50 Free Radical Scavengers
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Chemical characterization, antioxidant, genotoxic and in vitro cytotoxic activity assessment of Juniperus communis var. saxatilis.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Dec 26, 2017
Chemical composition and antioxidative, genotoxic and cytotoxic potential of essential oil (EO) and post-distillation waste (PDW) of Serbian Juniperus communis L. var. saxatilis Pall. was studied in human lung carcinoma (A549) and normal lung fibrobl...
Mutagens Cell Division G2 Phase Humans Juniperus Female Drug Screening Assays, Antitumor Animals Tandem Mass Spectrometry Male Gas Chromatography-Mass Spectrometry Doxorubicin Apoptosis Cell Line, Tumor Cell Line Antioxidants Antineoplastic Agents, Phytogenic Plant Extracts Chromatography, Liquid Rats
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5-fluorouracil combined with cisplatin and mitomycin C as an optimized regimen for hyperthermic intraperitoneal chemotherapy in gastric cancer.

Journal of surgical oncology Dec 19, 2017
BACKGROUND AND OBJECTIVES: Optimized drug regimens for hyperthermic intraperitoneal chemotherapy (HIPEC) have not been standardized completely in patients with advanced gastric cancer (GC). We evaluated an optimized anti-tumor protocol comprising 5-f...
Humans Stomach Neoplasms Cell Line, Tumor Antineoplastic Combined Chemotherapy Protocols Mitomycin Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Hyperthermia, Induced Cisplatin Cell Growth Processes Fluorouracil
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Effects of salinity on bacterial communities, Maillard reactions, isoflavone composition, antioxidation and antiproliferation in Korean fermented soybean paste (doenjang).

Food chemistry Oct 26, 2017
The purpose of this study was to investigate bacterial communities and health-benefit-related parameters in doenjang prepared with various brine concentrations (8, 12, 16, and 20%). Phenolic, flavonoid, melanoidin and isoflavone contents, antioxidati...
Humans Bacteria Antioxidants Cell Proliferation Phenols Drug Screening Assays, Antitumor Polymers Hydrogen-Ion Concentration Microbial Consortia Maillard Reaction Fermentation Soy Foods Fermented Foods Isoflavones Lactobacillus HT29 Cells
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Anticancer and anti-inflammatory activities of girinimbine isolated from .

Drug design, development and therapy Dec 28, 2016
Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a...
Tumor Cells, Cultured Murraya Anti-Inflammatory Agents, Non-Steroidal Zebrafish Alkaloids HT29 Cells Cell Proliferation Apoptosis Lipopolysaccharides Dose-Response Relationship, Drug Cell Survival Antineoplastic Agents, Phytogenic Drug Screening Assays, Antitumor Structure-Activity Relationship Cytokines Animals Mice Nitric Oxide Humans
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Predicting target proteins for drug candidate compounds based on drug-induced gene expression data in a chemical structure-independent manner.

BMC medical genomics Dec 18, 2015
BACKGROUND: Phenotype-based high-throughput screening is a useful technique for identifying drug candidate compounds that have a desired phenotype. However, the molecular mechanisms of the hit compounds remain unknown, and substantial effort is requi...
Humans Machine Learning Drug Screening Assays, Antitumor MCF-7 Cells Structure-Activity Relationship HL-60 Cells Neoplasms Antineoplastic Agents Transcriptome Gene Expression Regulation, Neoplastic
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Low-cost robotic manipulation of live microtissues for cancer drug testing.

Science advances May 16, 2025
The scarcity of human biopsies available for drug testing is a paramount challenge for developing therapeutics, disease models, and personalized treatments. Microtechnologies that combine the microscale manipulation of tissues and fluids offer the ex...
Antineoplastic Agents Drug Screening Assays, Antitumor Robotics Lab-On-A-Chip Devices Humans Neoplasms
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A Novel Effective Models for Identifying BRCA Patients and Optimizing Clinical Treatments.

Anti-cancer agents in medicinal chemistry Jan 1, 2025
OBJECTIVE: This study aimed to develop an effective model that identifies high-risk breast cancer (BRCA) patients and optimizes clinical treatments.
Prognosis Female Breast Neoplasms Antineoplastic Agents Humans Machine Learning Cell Proliferation Drug Screening Assays, Antitumor
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PySmash: Python package and individual executable program for representative substructure generation and application.

Briefings in bioinformatics Sep 2, 2021
BACKGROUND: Substructure screening is widely applied to evaluate the molecular potency and ADMET properties of compounds in drug discovery pipelines, and it can also be used to interpret QSAR models for the design of new compounds with desirable phys...
Carcinogens Carcinogenicity Tests Humans Machine Learning Software Drug Discovery Computational Biology Drug Screening Assays, Antitumor
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Anticancer drug synergy prediction in understudied tissues using transfer learning.

Journal of the American Medical Informatics Association : JAMIA Jan 15, 2021
OBJECTIVE: Drug combination screening has advantages in identifying cancer treatment options with higher efficacy without degradation in terms of safety. A key challenge is that the accumulated number of observations in in-vitro drug responses varies...
Drug Screening Assays, Antitumor Drug Synergism Cell Line, Tumor Computational Biology Models, Theoretical Drug Combinations Humans Neural Networks, Computer Machine Learning Antineoplastic Agents
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