AIMC Topic: Drug Stability

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The effects of environmental and compositional manipulations on the longevity of Tessari-made foam for sclerotherapy.

Journal of vascular surgery. Venous and lymphatic disorders Sep 4, 2014
BACKGROUND: Tessari-made foam sclerotherapy is performed around the world in a variety of clinics differing in methods, equipment, temperatures, and altitudes. We investigated how the following factors affected the foam's longevity: silicone vs nonsi...
Drug Stability Syringes Silicones Carbon Dioxide Half-Life Sclerosing Solutions Temperature Time Factors Sclerotherapy Polyethylene Glycols
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Combining machine learning and molecular simulations to predict the stability of amorphous drugs.

The Journal of chemical physics Jul 7, 2023
Amorphous drugs represent an intriguing option to bypass the low solubility of many crystalline formulations of pharmaceuticals. The physical stability of the amorphous phase with respect to the crystal is crucial to bring amorphous formulations into...
Solubility Drug Stability Crystallization Machine Learning Drug Design
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Stability and compatibility of methotrexate and dexamethasone in 0.9% sodium chloride for intrathecal injection.

Pakistan journal of pharmaceutical sciences Nov 1, 2020
The stability of a mixture of methotrexate and dexamethasone sodium phosphate in 0.9% sodium chloride for intrathecal (IT) injection was assessed. To simulate the clinically used concentrations of the admixtures, 2mL of 0.9% sodium chloride was added...
Drug Storage Chromatography, High Pressure Liquid Injections, Spinal Dexamethasone Sodium Chloride Methotrexate Drug Stability
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Reverse-Phase Chromatographic Determination and Intrinsic Stability Behavior of 5-[(4-Chlorophenoxy)Methyl]-1,3,4-Oxadiazole-2-Thiol.

Acta pharmaceutica (Zagreb, Croatia) Dec 1, 2018
The study describes the development and preliminary validation of a simple reverse-phase chromatographic method for determination of a novel drug candidate, 5-[(4-chlorophenoxy) methyl]-1,3,4-oxadiazole-2-thiol (OXCPM), in bulk and stressed solution,...
Chromatography, Reverse-Phase Chromatography, High Pressure Liquid Temperature Drug Stability Reproducibility of Results Oxadiazoles Hydrogen-Ion Concentration
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Stability of 90 mg/mL cefuroxime sodium solution for administration by continuous infusion.

Journal of chemotherapy (Florence, Italy) Jan 1, 2018
Continuous infusions of β-lactam antibiotics increase pharmacokinetic/pharmacodynamic target attainment. However, this way of administration brings about some practical issues such as stability. This study aims to determine the stability of a 90 mg/m...
Syringes Infusions, Intravenous Sodium Cefuroxime Chromatography, High Pressure Liquid Drug Stability Polypropylenes
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The use of experimental design for the development of a capillary zone electrophoresis method for the quantitation of captopril.

Die Pharmazie Sep 1, 2017
A capillary zone electrophoresis (CZE) method for the quantitation of captopril (CPT) using UV detection was developed. Influence of electrolyte concentration and system variables on electrophoretic separation was evaluated and a central composite de...
Reproducibility of Results Linear Models Angiotensin-Converting Enzyme Inhibitors Electrophoresis, Capillary Drug Stability Captopril Sulfites Limit of Detection
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Caspofungin infusion solutions (50 mg/100 mL): chemical stability and antifungal activity against Candida spp.

Die Pharmazie Apr 1, 2017
BACKGROUND: Ready to use caspofungin infusion bags are centrally prepared in the Hospital Pharmacy, University Hospital of Heidelberg, for economic reasons and possibly occurring problems with drug shortages. The aim of this study was a quality contr...
Drug Stability Drug Storage Sodium Chloride Antifungal Agents Chromatography, High Pressure Liquid Echinocandins Infusions, Parenteral Pharmaceutical Solutions Lipopeptides Caspofungin Microbial Sensitivity Tests Time Factors Candida
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DEVELOPMENT AND VALIDATION OF FAST REVERSED-PHASE HPLC METHOD FOR ANALYSIS OF ESOMEPRAZOLE IN RABBIT PLASMA.

Acta poloniae pharmaceutica Mar 1, 2017
The present study focused to develop rapid, accurate and sensitive reversed-phase high pressure liquid chromatography method for the quantification of esomeprazole (ESO) magnesium in rabbit plasma. Chromatographic separation was achieved isocraticall...
Hydrogen-Ion Concentration Chromatography, High Pressure Liquid Acetonitriles Reproducibility of Results Proton Pump Inhibitors Animals Drug Monitoring Solvents Cold Temperature Limit of Detection Esomeprazole Methanol Spectrophotometry, Ultraviolet Freezing Drug Stability Rabbits Linear Models Potassium Compounds Hydroxides Buffers Chromatography, Reverse-Phase
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STABILITY INDICATIVE HPLC DETERMINATION OF RELATED SUBSTANCES AND IDENTIFICATION OF POTENTIAL DEGRADANTS USING LC-MS IN TRIPLE COMBINATION ANTIRETROVIRAL TABLETS.

Acta poloniae pharmaceutica Jan 1, 2017
A rapid stability indicating liquid chromatography method was developed and validated for the simultaneous quantitation of related substances of antiretrovirals in combined oral dosage formulation. Separation was achieved using a Waters, Xterra RP-18...
Tandem Mass Spectrometry Drug Stability Anti-Retroviral Agents Chromatography, High Pressure Liquid Drug Combinations Tablets
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STABILITY-INDICATING HPLC METHOD FOR DETERMINATION OF VANCOMYCIN HYDROCHLORIDE IN THE PHARMACEUTICAL DOSAGE FORMS.

Acta poloniae pharmaceutica Jan 1, 2017
A simple, rapid and selective RP-HPLC method was developed for the determination of vancomycin hydrochloride. The separation was achieved using a Capital C8-Optimal column (250 x 4.6 mm i.d., 5 μm particle size) with a mobile phase composed of buffer...
Drug Stability Vancomycin Chromatography, Reverse-Phase Chromatography, High Pressure Liquid
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