AIMC Topic: Drug Synergism

Clear Filters Showing 51 to 59 of 59 articles

Anticancer drug synergy prediction in understudied tissues using transfer learning.

Journal of the American Medical Informatics Association : JAMIA Jan 15, 2021
OBJECTIVE: Drug combination screening has advantages in identifying cancer treatment options with higher efficacy without degradation in terms of safety. A key challenge is that the accumulated number of observations in in-vitro drug responses varies...
Machine Learning Antineoplastic Agents Cell Line, Tumor Drug Combinations Computational Biology Drug Screening Assays, Antitumor Models, Theoretical Humans Neural Networks, Computer Drug Synergism
View on PubMed DOI

Synergistic Drug Combination Prediction by Integrating Multiomics Data in Deep Learning Models.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2021
Intrinsic and acquired drug resistance is a major challenge in cancer therapy. Synergistic drug combinations could help to overcome drug resistance. However, the number of possible drug combinations is enormous, and it is infeasible to experimentally...
Databases, Factual Computer Simulation Neoplasms Gene Expression Profiling Humans Antineoplastic Combined Chemotherapy Protocols Neural Networks, Computer Drug Combinations Databases, Genetic Drug Synergism Deep Learning Cell Line, Tumor Computational Biology
View on PubMed DOI

Antimicrobial and synergistic activity of thiazoline derivatives in combination with conventional antibiotics against multidrug resistant Staphylococcus aureus isolated from abscess drainage samples.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
Emergence and spread of multidrug resistant (MDR) Staphylococcus aureus strains is becoming major challenge in treatment of soft tissue infections. This study aimed to explore antimicrobial and synergistic antimicrobial potential of three commerciall...
Drug Synergism Abscess Staphylococcus aureus Disk Diffusion Antimicrobial Tests Drainage Thiazoles Staphylococcal Infections Thiazolidines Humans Drug Therapy, Combination Anti-Bacterial Agents Ribotyping Drug Resistance, Multiple, Bacterial
View on PubMed

Investigating the anti-angiogenic effects of Fufang Kushen Injection in combination with cisplatin using a zebrafish model.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
The Traditional Chinese Medicine formula Fufang Kushen Injection (FKI) has demonstrated potential to enhance the efficacy and reduce the toxicity of the chemotherapeutic drug cisplatin. However, there is insufficient evidence to determine whether the...
Drugs, Chinese Herbal Cisplatin Zebrafish Animals Angiogenesis Inhibitors Dose-Response Relationship, Drug Vascular Endothelial Growth Factor Receptor-2 Zebrafish Proteins Neovascularization, Physiologic Drug Synergism Animals, Genetically Modified
View on PubMed

Predicting drug synergy for precision medicine using network biology and machine learning.

Journal of bioinformatics and computational biology Apr 1, 2019
Identification of effective drug combinations for patients is an expensive and time-consuming procedure, especially for experiments. To accelerate the synergistic drug discovery process, we present a new classification model to identify more effecti...
Databases, Pharmaceutical Computational Biology Drug Synergism Gene Ontology Humans Machine Learning Transcriptome Protein Interaction Maps Precision Medicine Reproducibility of Results
View on PubMed DOI

Prediction of drug synergy score using ensemble based differential evolution.

IET systems biology Feb 1, 2019
Prediction of drug synergy score is an ill-posed problem. It plays an efficient role in the medical field for inhibiting specific cancer agents. An efficient regression-based machine learning technique has an ability to minimise the drug synergy pred...
Time Factors Computational Biology Support Vector Machine Drug Synergism
View on PubMed DOI

Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate.

Pharmaceutical biology Dec 1, 2018
CONTEXT: Garcinia mangostana Linn. (Guttiferae) pericarp is used as a traditional medicine in South Asia to treat inflammatory diseases.
Drug Synergism Drug Therapy, Combination Collagen Arthritis, Experimental Drugs, Chinese Herbal Methotrexate Garcinia mangostana Rats Ethanol Rats, Sprague-Dawley Animals Male
View on PubMed DOI

A Fresh Shine onCystic Fibrosis Inhalation Therapy: Antimicrobial Synergy of Polymyxin B in Combination with Silver Nanoparticles.

Journal of biomedical nanotechnology Apr 1, 2017
This in vitro study aimed to investigate the synergistic antibacterial activity of polymyxin B in combination with 2 nm silver nanoparticles (NPs) against Gram-negative pathogens commonly isolated from the cystic fibrosis (CF) lung. The in vitro syne...
Drug Synergism Metal Nanoparticles Bacterial Physiological Phenomena Silver Administration, Inhalation Diffusion Respiratory Therapy Cystic Fibrosis Pneumonia, Bacterial Drug Combinations Polymyxin B Dose-Response Relationship, Drug Cell Survival Humans Anti-Infective Agents Treatment Outcome
View on PubMed DOI

Doxorubicin enhances (131)I-rituximab induced cell death in Raji cells.

Journal of cancer research and therapeutics Jan 1, 2015
AIM: There are various therapeutic modalities of treatment for non-Hodgkin's lymphoma, but with certain limitations, hence, investigating the scope of combined therapeutic approach.
Humans Poly(ADP-ribose) Polymerases Flow Cytometry Burkitt Lymphoma Radiation-Sensitizing Agents Radiopharmaceuticals Doxorubicin Tumor Cells, Cultured Rituximab Iodine Radioisotopes Drug Synergism Antineoplastic Combined Chemotherapy Protocols Apoptosis Blotting, Western RNA, Messenger Cell Proliferation Signal Transduction
View on PubMed DOI
Popular Topics
Recent Journals