AIMC Topic: Drugs, Chinese Herbal

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Insight into endophytic microbiota-driven geographical and bioactive signatures toward a novel quality assessment model for Codonopsis Radix.

Plant physiology and biochemistry : PPB
Codonopsis Radix, a medicinal and dietary herb in traditional Chinese medicine, largely owes its pharmacological efficacy to both intrinsic phytochemistry and symbiotic interactions with plant-associated microbes. Here, we deciphered the geo-environm...

Niuhuang jiedu prescription alleviates realgar-induced dopaminergic and GABAergic neurotoxicity in Caenorhabditis elegans.

Journal of ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE: Niuhuang Jiedu (NHJD) is a Chinese medicine prescription containing realgar (AsS), which is neurotoxic, and seven other traditional Chinese medicines (TCMs). However, whether the multiple TCMs contained in NHJD can mit...

Shengxuebao Mixture improves carboplatin-induced anemia by inhibiting apoptosis and ferroptosis.

Journal of ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE: Shengxuebao Mixture (SXB) is a traditional Chinese medicine which has been widely used on treating Chemotherapy-induced leukopenia and multiple anemia. It remains unclear whether SXB has a role in chemotherapeutic-indu...

DMC-LIBSAS: A Laser-Induced Breakdown Spectroscopy Analysis System with Double-Multi Convolutional Neural Network for Accurate Traceability of Chinese Medicinal Materials.

Sensors (Basel, Switzerland)
Against the background of globalization, the circulation range of traditional Chinese medicinal materials is constantly expanding, and the phenomena of mixed origins and counterfeiting are becoming increasingly serious. Tracing the origin of traditio...

Deciphering the Pharmacological Potential of Kouqiangjie Formula for the Treatment of Diabetic Periodontitis Based on Network Pharmacology, Machine Learning, Molecular Dynamics, and Animal Experiments.

Drug design, development and therapy
BACKGROUND: Periodontitis (PD) and type 2 diabetes mellitus (T2DM) represent interlinked global health burdens, commonly causing significant clinical complications when coincident. Therefore, managing both conditions (T2DM with periodontitis, DP) sim...

Therapeutic potential of Da Cheng Qi Decoction and its ingredients in regulating ferroptosis via the NOX2-GPX4 signaling pathway to alleviate and predict severe acute pancreatitis.

Cellular signalling
OBJECTIVE: This study aimed to elucidate the protective effects of Da Cheng Qi Decoction (DCQD) on severe acute pancreatitis (SAP) by targeting ferroptosis in pancreatic acinar cells and to establish a predictive signature and nomogram for acute panc...

An quality evaluation method based on three-dimensional integration and machine learning: Advanced data processing.

Journal of chromatography. A
This study presents an innovative approach for the quality evaluation of traditional Chinese medicine (TCM) by integrating three-dimensional (3D) data processing with machine learning, aimed at enhancing the efficiency and accuracy of HPLC-DAD data a...

Using near-infrared hyperspectral imaging combined with machine learning to predict the components and the origin of Radix Paeoniae Rubra.

Analytical methods : advancing methods and applications
The efficacy and safety of drugs are closely related to the geographical origin and quality of the raw materials. This study focuses on using near-infrared hyperspectral imaging (NIR-HSI) combined with machine learning algorithms to construct content...

A holistic strategy for the in-depth discrimination and authentication of 16 citrus herbs and associated commercial products based on machine learning techniques and non-targeted metabolomics.

Journal of chromatography. A
Citrus-derived raw medicinal materials are frequently used for health care, flavoring, and therapeutic purposes. However, Due to similarities in origin or appearance, citrus herbs are often misused in the market, necessitating effective differentiati...