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Energy Metabolism

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Serum Peroxisome Proliferator-activated Receptor Gamma Coactivator-1α Related to Myocardial Energy Expenditure in Patients With Chronic Heart Failure.

The American journal of the medical sciences
BACKGROUND: Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) plays key roles in controlling cardiac metabolism and function. Myocardial energy expenditure (MEE) can reflect myocardial energy metabolism and cardiac function. Wh...

Data-driven supervised learning of a viral protease specificity landscape from deep sequencing and molecular simulations.

Proceedings of the National Academy of Sciences of the United States of America
Biophysical interactions between proteins and peptides are key determinants of molecular recognition specificity landscapes. However, an understanding of how molecular structure and residue-level energetics at protein-peptide interfaces shape these l...

Rapid energy expenditure estimation for ankle assisted and inclined loaded walking.

Journal of neuroengineering and rehabilitation
BACKGROUND: Estimating energy expenditure with indirect calorimetry requires expensive equipment and several minutes of data collection for each condition of interest. While several methods estimate energy expenditure using correlation to data from w...

Metabolic cost adaptations during training with a soft exosuit assisting the hip joint.

Scientific reports
Different adaptation rates have been reported in studies involving ankle exoskeletons designed to reduce the metabolic cost of their wearers. This work aimed to investigate energetic adaptations occurring over multiple training sessions, while walkin...

Prediction of metabolic status of dairy cows in early lactation with on-farm cow data and machine learning algorithms.

Journal of dairy science
Metabolic status of dairy cows in early lactation can be evaluated using the concentrations of plasma β-hydroxybutyrate (BHB), free fatty acids (FFA), glucose, insulin, and insulin-like growth factor 1 (IGF-1). These plasma metabolites and metabolic ...

Neural-network classification of cardiac disease from P cardiovascular magnetic resonance spectroscopy measures of creatine kinase energy metabolism.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
BACKGROUND: The heart's energy demand per gram of tissue is the body's highest and creatine kinase (CK) metabolism, its primary energy reserve, is compromised in common heart diseases. Here, neural-network analysis is used to test whether noninvasive...

Metabolomics meets machine learning: Longitudinal metabolite profiling in serum of normal versus overconditioned cows and pathway analysis.

Journal of dairy science
This study aimed to investigate the differences in the metabolic profiles in serum of dairy cows that were normal or overconditioned when dried off for elucidating the pathophysiological reasons for the increased health disturbances commonly associat...

MMPdb and MitoPredictor: Tools for facilitating comparative analysis of animal mitochondrial proteomes.

Mitochondrion
Data on experimentally-characterized animal mitochondrial proteomes (mt-proteomes) are limited to a few model organisms and are scattered across multiple databases, impeding a comparative analysis. We developed two resources to address these problems...

Improving energy expenditure estimates from wearable devices: A machine learning approach.

Journal of sports sciences
A means of quantifying continuous, free-living energy expenditure (EE) would advance the study of bioenergetics. The aim of this study was to apply a non-linear, machine learning algorithm (random forest) to predict minute level EE for a range of act...

A biarticular passive exosuit to support balance control can reduce metabolic cost of walking.

Bioinspiration & biomimetics
Nowadays, the focus on the development of assistive devices just for people with mobility disorders has shifted towards enhancing physical abilities of able-bodied humans. As a result, the interest in the design of cheap and soft wearable exoskeleton...