Diagnostic microbiology and infectious disease
Nov 30, 2015
Clostridium difficile infection is often overdiagnosed in patients with mild diarrhea. We evaluated 4 biomarkers as surrogates for clinically significant diarrhea (≥ 3 episodes in 24 hours) in 59 PCR-positive patients with and 59 PCR-positive patient...
Traditional fecal erythrocyte detection is performed via a manual operation that is unsuitable because it depends significantly on the expertise of individual inspectors. To recognize human erythrocytes automatically and precisely, automatic segmenta...
The objectives were to evaluate the presence of vancomycin-resistant enterococci with acquired (VRE-a) and intrinsic (VRE-i) resistance mechanisms in fecal samples from different wild animals, and analyze their phenotypes and genotypes of antimicrobi...
In this study we use a machine learning software (Ichnaea) to generate predictive models for water samples with different concentrations of fecal contamination (point source, moderate and low). We applied several MST methods (host-specific Bacteroide...
Clinical pharmacology in drug development
Dec 11, 2014
Absolute oral bioavailability of canagliflozin was assessed by simultaneous oral administration with intravenous [(14) C]-canagliflozin microdose infusion in nine healthy men. Pharmacokinetics of canagliflozin, [(14) C]-canagliflozin, and total radio...
Escherichia coli recovered from dogs with clinical conditions such as urinary tract infections are often used to assess populations for resistance to critically important antimicrobials (CIAs). Despite the potential importance of such strains, the nu...
BACKGROUND/AIM: This study aimed to evaluate the diagnostic accuracy (DA) of four artificial intelligence (AI) models compared to logistic regression (LR) in enhancing the performance of the fecal immunochemical test (FIT) for the detection of colore...
BACKGROUND AND AIMS: Insufficient bowel preparation accounts for up to 42% of missed adenomas in colonoscopy. However, major analysis programs found no correlation between adenoma detection rate and the human-rated Boston Bowel Preparation Scale (BBP...
There are currently no licensed vaccines for norovirus, a leading cause of epidemic and endemic gastroenteritis worldwide. Clinical advancement of promising vaccine candidates from phase 2 studies to phase 3 field trials has been hampered by the lack...
BACKGROUND: The microbiome of adolescents is poorly understood, as are factors influencing its composition. We aimed to describe the healthy adolescent microbiome and identify early-life and concurrent predictors of its composition.
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