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Circulating proteins and metabolites panel for noninvasive preoperative diagnosis of epithelial ovarian cancer.

BMC medicine
BACKGROUND: Existing biomarkers for epithelial ovarian cancer (EOC) have demonstrated limited sensitivity and specificity. This study aimed to investigate plasma protein and metabolite characteristics of EOC and identify novel biomarker candidates fo...

Study on the mechanisms associating community outdoor public spaces with elderly behavior.

Scientific reports
As the global population ages, enhancing community outdoor public spaces to accommodate the needs of senior citizens has emerged as a critical challenge. This research delves into the intricate relationship between community outdoor public spaces and...

Radiomics early assessment of post chemotherapy cardiotoxicity in cancer patients using 2D echocardiography imaging an interpretable machine learning study.

Scientific reports
Cardiotoxicity is the loss of the heart muscle's ability to contract effectively, often due to chemotherapy or radiation therapy. This study uses interpretable machine learning to predict post-chemotherapy cardiotoxicity using radiomics features extr...

Use of computer vision analysis for labeling inattention periods in EEG recordings with visual stimuli.

Scientific reports
Electroencephalography (EEG) recordings with visual stimuli require detailed coding to determine the periods of participant's attention. Here we propose to use a supervised machine learning model and off-the-shelf video cameras only. We extract compu...

Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha.

Nature communications
Target identification in natural products plays a critical role in the development of innovative drugs. Bufalin, a compound derived from traditional medicines, has shown promising anti-cancer activity; however, its precise molecular mechanism of acti...

Human iPSC-derived spinal neural progenitors enhance sensorimotor recovery in spinal cord-injured NOD-SCID mice via differentiation and microenvironment regulation.

Cell death & disease
Spinal cord injury (SCI) remains a significant clinical challenge and poses a dramatic threat to the life quality of patients due to limited neural regeneration and detrimental post-injury alternations in tissue microenvironment. We developed a thera...

Decoding target discriminability and time pressure using eye and head movement features in a foraging search task.

Cognitive research: principles and implications
In military operations, rapid and accurate decision-making is crucial, especially in visually complex and high-pressure environments. This study investigates how eye and head movement metrics can infer changes in search behavior during a naturalistic...

Constructing a predictive model for acute mastitis in lactating women based on machine learning.

Scientific reports
Acute lactational mastitis is a frequently occurring complication for lactating women, exerting a certain degree of influence on their physical condition, breastfeeding, mental health, and daily life. The etiology of this disease is complex, and the ...

Machine learning enhanced expert system for detecting heart failure decompensation using patient reported vitals and electronic health records.

Scientific reports
Heart failure (HF) is a condition with periods of stability interrupted by periods of worsening symptoms, known as decompensation episodes. Digital interventions are promising tools to alleviate burdens on HF management through automated alerts at th...

Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study.

Translational psychiatry
Previous studies have found that major depressive disorder (MDD) may accelerate overall structural brain aging. Nevertheless, it still remains unknown whether anhedonia, a critical negative prognostic indicator in MDD, further leads to advanced brain...