European journal of medicinal chemistry
Nov 6, 2025
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited treatment options. Wee1 kinase, a critical regulator of the G2/M checkpoint and DNA replication, is a promising therapeutic target. However, dose dependent as...
BACKGROUND: There is a growing need for alternative imaging measures to better understand the neurodegenerative pathology of Parkinson's disease and related conditions, such as drug-induced Parkinsonism. This study investigated the link between optic...
Lupus nephritis (LN), a severe renal complication of systemic lupus erythematosus (SLE), results from immune abnormalities. Qingre Kasen granules (QS), which have chicory as the main ingredient, play a significant role in treating various inflammator...
Journal of the American Heart Association
Nov 6, 2025
BACKGROUND: Artificial intelligence-guided quantitative computed tomography ischemia (AI-QCT) is a novel machine-learning method for predicting myocardial ischemia from coronary computed tomography angiography (CCTA). This observational cohort study ...
BMC medical informatics and decision making
Nov 6, 2025
BACKGROUND: Adolescent depression is a major public health concern. Physical health indicators are rarely included in risk tools. We examined whether adding dry eye disease (DED) to psychosocial and behavioral factors improves prediction of depressiv...
Accurately estimating energy requirements is critical for individuals to maintain a healthy life. Traditional methods may be time-consuming, complex, low in accuracy, and costly, thus creating a need for new approaches. This study explores the applic...
Triple-negative breast cancer (TNBC) is characterized by poor prognosis and limited targeted treatment options. Efferocytosis, an essential immune mechanism for the clearance of apoptotic cells, is increasingly recognized as a key contributor to tumo...
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms, including gait impairments, which significantly affect patient mobility and quality of life. An accurate assessment of the severity of PD is crucial for clinica...
The adoption of the Internet of Things (IoT) for the application of smart health is an effective method for distributed and intelligent automated diagnosis systems. Fetal movement is a basic index of fetal well being. IoT based fetal health classific...
The transition out of military service and into civilian life represents a considerable challenge for many military veterans. In this study we used mixture growth modeling and random forest analysis to examine predictors of adjustment to civilian lif...
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