AIMC Topic: Gene Expression Profiling

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HDG-select: A novel GUI based application for gene selection and classification in high dimensional datasets.

PloS one
The selection and classification of genes is essential for the identification of related genes to a specific disease. Developing a user-friendly application with combined statistical rigor and machine learning functionality to help the biomedical res...

Identification of drug combinations on the basis of machine learning to maximize anti-aging effects.

PloS one
Aging is a multifactorial process that involves numerous genetic changes, so identifying anti-aging agents is quite challenging. Age-associated genetic factors must be better understood to search appropriately for anti-aging agents. We utilized an ag...

Machine learning approaches reveal subtle differences in breathing and sleep fragmentation in -derived astrocytes ablated mice.

Journal of neurophysiology
Modern neurophysiology research requires the interrogation of high-dimensionality data sets. Machine learning and artificial intelligence (ML/AI) workflows have permeated into nearly all aspects of daily life in the developed world but have not been ...

Machine Learning Analysis of Longevity-Associated Gene Expression Landscapes in Mammals.

International journal of molecular sciences
One of the important questions in aging research is how differences in transcriptomics are associated with the longevity of various species. Unfortunately, at the level of individual genes, the links between expression in different organs and maximum...

Mining influential genes based on deep learning.

BMC bioinformatics
BACKGROUND: Currently, large-scale gene expression profiling has been successfully applied to the discovery of functional connections among diseases, genetic perturbation, and drug action. To address the cost of an ever-expanding gene expression prof...

On transformative adaptive activation functions in neural networks for gene expression inference.

PloS one
Gene expression profiling was made more cost-effective by the NIH LINCS program that profiles only ∼1, 000 selected landmark genes and uses them to reconstruct the whole profile. The D-GEX method employs neural networks to infer the entire profile. H...

Prediction of future gene expression profile by analyzing its past variation pattern.

Gene expression patterns : GEP
A number of initial Hematopoietic Stem Cells (HSC) are considered in a container that are able to divide into HSCs or differentiate into various types of descendant cells. In this paper, a method is designed to predict an approximate gene expression ...

A 9 mRNAs-based diagnostic signature for rheumatoid arthritis by integrating bioinformatic analysis and machine-learning.

Journal of orthopaedic surgery and research
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune rheumatic disease that carries a substantial burden for both patients and society. Early diagnosis of RA is essential to prevent disease progression and select an optimal therapeutic strategy. Ho...

A novel gene expression test method of minimizing breast cancer risk in reduced cost and time by improving SVM-RFE gene selection method combined with LASSO.

Journal of integrative bioinformatics
Breast cancer is the leading diseases of death in women. It induces by a genetic mutation in breast cancer cells. Genetic testing has become popular to detect the mutation in genes but test cost is relatively expensive for several patients in develop...