AIMC Topic: Gene Regulatory Networks

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Inferring Gene Regulatory Networks of Metabolic Enzymes Using Gradient Boosted Trees.

IEEE journal of biomedical and health informatics Jul 30, 2019
Metabolic reprogramming is a hallmark of cancer. In cancer cells, transcription factors (TFs) govern metabolic reprogramming through abnormally increasing or decreasing the transcription rate of metabolic enzymes, which provides cancer cells growth a...
Enzymes Algorithms Gene Expression Profiling Transcriptome Gene Regulatory Networks Lung Neoplasms Transcription Factors Humans Machine Learning
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Screening and Bioinformatics Analysis of IgA Nephropathy Gene Based on GEO Databases.

BioMed research international Jul 16, 2019
PURPOSE: To identify novel biomarkers of IgA nephropathy (IgAN) through bioinformatics analysis and elucidate the possible molecular mechanism.
Gene Ontology Computational Biology Glomerulonephritis, IGA Databases, Nucleic Acid MAP Kinase Signaling System Humans Gene Expression Profiling Gene Regulatory Networks
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Machine learning approaches to predict lupus disease activity from gene expression data.

Scientific reports Jul 3, 2019
The integration of gene expression data to predict systemic lupus erythematosus (SLE) disease activity is a significant challenge because of the high degree of heterogeneity among patients and study cohorts, especially those collected on different mi...
Disease Progression Gene Expression ROC Curve Gene Expression Profiling Gene Regulatory Networks Lupus Erythematosus, Systemic Gene Expression Regulation Transcriptome Computational Biology Molecular Sequence Annotation Humans Machine Learning
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GAIL: An interactive webserver for inference and dynamic visualization of gene-gene associations based on gene ontology guided mining of biomedical literature.

PloS one Jul 1, 2019
In systems biology, inference of functional associations among genes is compelling because the construction of functional association networks facilitates biomarker discovery. Specifically, such gene associations in human can help identify putative b...
Publications Data Mining Humans Gene Ontology Software Gene Regulatory Networks Biomarkers Systems Biology User-Computer Interface Internet Data Visualization
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Domain transformation on biological event extraction by learning methods.

Journal of biomedical informatics Jun 18, 2019
Event extraction and annotation has become a significant focus of recent efforts in biological text mining and information extraction (IE). However, event extraction, event annotation methods, and resources have so far focused almost exclusively on a...
Animals Deep Learning Gene Regulatory Networks Databases, Factual Data Curation Natural Language Processing Models, Biological Data Mining
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Assessment of risk based on variant pathways and establishment of an artificial neural network model of thyroid cancer.

BMC medical genetics May 28, 2019
BACKGROUND: This study aimed to establish an artificial neural network (ANN) model based on variant pathways to predict the risk of thyroid cancer.
Gene Expression Profiling Thyroid Neoplasms Gene Regulatory Networks Gene Expression Regulation, Neoplastic Signal Transduction Cluster Analysis Neural Networks, Computer Risk Factors Biomarkers, Tumor Humans
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Screening of disorders associated with osteosarcoma by integrated network analysis.

Bioscience reports May 21, 2019
Osteosarcoma is a common malignant bone tumor in children and adolescents under the age of 20. However, research on the pathogenesis and treatment of osteosarcoma is still insufficient. In the present study, based on gene-phenotype correlation networ...
Gene Expression Regulation, Neoplastic Osteosarcoma Bone Neoplasms Humans Gene Expression Profiling Gene Regulatory Networks Neoplasm Proteins Gene Ontology
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Deep Learning/Artificial Intelligence and Blood-Based DNA Epigenomic Prediction of Cerebral Palsy.

International journal of molecular sciences Apr 27, 2019
The etiology of cerebral palsy (CP) is complex and remains inadequately understood. Early detection of CP is an important clinical objective as this improves long term outcomes. We performed genome-wide DNA methylation analysis to identify epigenomic...
Cell-Free Nucleic Acids CpG Islands Cerebral Palsy Epigenesis, Genetic Infant, Newborn Epigenomics Gene Expression Profiling DNA Methylation Case-Control Studies Deep Learning Humans ROC Curve Artificial Intelligence Gene Regulatory Networks
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Predicting miRNA-lncRNA interactions and recognizing their regulatory roles in stress response of plants.

Mathematical biosciences Apr 26, 2019
It has been found that each non-coding RNA (ncRNA) can act not only through its target gene, but also interact with each other to act on biological traits, and this interaction is more common. Many studies focus mainly on the analysis of microRNA(miR...
Gene Regulatory Networks RNA, Messenger Models, Genetic Stress, Physiological Arabidopsis RNA, Plant Support Vector Machine MicroRNAs RNA, Long Noncoding
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Systems Pharmacological Approach to Investigate the Mechanism of for Application to Alzheimer's Disease.

Molecules (Basel, Switzerland) Apr 17, 2019
(OC)-a traditional Chinese medicine (TCM)-has been reported to have large numbers of flavonoids, alkaloids, and triterpenoids. The previous studies on OC for treating Alzheimer's disease (AD) only focused on single targets and its mechanisms, while ...
Gene Expression Regulation Humans Gene Ontology Gene Regulatory Networks Signal Transduction Alzheimer Disease Biological Availability Drugs, Chinese Herbal Fabaceae
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