AIMC Topic: Genome-Wide Association Study

Clear Filters Showing 111 to 120 of 287 articles

Artificial intelligence and leukocyte epigenomics: Evaluation and prediction of late-onset Alzheimer's disease.

PloS one Mar 31, 2021
We evaluated the utility of leucocyte epigenomic-biomarkers for Alzheimer's Disease (AD) detection and elucidates its molecular pathogeneses. Genome-wide DNA methylation analysis was performed using the Infinium MethylationEPIC BeadChip array in 24 l...
Deep Learning Genome-Wide Association Study Epigenesis, Genetic Epigenomics Sensitivity and Specificity Male Case-Control Studies CpG Islands Late Onset Disorders Signal Transduction DNA Methylation Leukocytes Alzheimer Disease Humans Biomarkers Prognosis Female Aged Aged, 80 and over
View on PubMed DOI

A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes.

Nature communications Mar 12, 2021
Conventional human leukocyte antigen (HLA) imputation methods drop their performance for infrequent alleles, which is one of the factors that reduce the reliability of trans-ethnic major histocompatibility complex (MHC) fine-mapping due to inter-ethn...
Racial Groups Genome-Wide Association Study Linkage Disequilibrium Genetic Predisposition to Disease Genotype HLA Antigens Major Histocompatibility Complex Humans Diabetes Mellitus, Type 1 Histocompatibility Antigens Class II Alleles Deep Learning Histocompatibility Antigens Class I Ethnicity
View on PubMed DOI

CADD-Splice-improving genome-wide variant effect prediction using deep learning-derived splice scores.

Genome medicine Feb 22, 2021
BACKGROUND: Splicing of genomic exons into mRNAs is a critical prerequisite for the accurate synthesis of human proteins. Genetic variants impacting splicing underlie a substantial proportion of genetic disease, but are challenging to identify beyond...
Exons Humans Genetic Variation Deep Learning Base Sequence Genome-Wide Association Study Introns RNA Splicing
View on PubMed DOI

Forest and Trees: Exploring Bacterial Virulence with Genome-wide Association Studies and Machine Learning.

Trends in microbiology Jan 14, 2021
The advent of inexpensive and rapid sequencing technologies has allowed bacterial whole-genome sequences to be generated at an unprecedented pace. This wealth of information has revealed an unanticipated degree of strain-to-strain genetic diversity w...
Machine Learning Phylogeny Genome, Bacterial Bacteria Genome-Wide Association Study Virulence Factors Genomics Virulence Genotype Genetic Variation
View on PubMed DOI

Systems Approach to Pathogenic Mechanism of Type 2 Diabetes and Drug Discovery Design Based on Deep Learning and Drug Design Specifications.

International journal of molecular sciences Dec 26, 2020
In this study, we proposed a systems biology approach to investigate the pathogenic mechanism for identifying significant biomarkers as drug targets and a systematic drug discovery strategy to design a potential multiple-molecule targeting drug for t...
Humans Gene Regulatory Networks Case-Control Studies Biomarkers Genetic Predisposition to Disease Epigenomics Deep Learning Drug Design Hypoglycemic Agents Computational Biology Genome-Wide Association Study Drug Discovery Systems Biology Diabetes Mellitus, Type 2
View on PubMed DOI

Identification of biological correlates associated with respiratory failure in COVID-19.

BMC medical genomics Dec 11, 2020
BACKGROUND: Coronavirus disease 2019 (COVID-19) is a global public health concern. Recently, a genome-wide association study (GWAS) was performed with participants recruited from Italy and Spain by an international consortium group.
Spain Gene Ontology Genome-Wide Association Study Polymorphism, Single Nucleotide Italy Respiratory Insufficiency Female SARS-CoV-2 Male Humans COVID-19
View on PubMed DOI

Statistical and Machine-Learning Analyses in Nutritional Genomics Studies.

Nutrients Oct 14, 2020
Nutritional compounds may have an influence on different OMICs levels, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, and metagenomics. The integration of OMICs data is challenging but may provide new knowledge to explain...
Humans Machine Learning Data Mining Genome-Wide Association Study Algorithms Nutrigenomics Cluster Analysis Nutritional Physiological Phenomena Data Interpretation, Statistical Nutrition Disorders Eating
View on PubMed DOI

Deep neural network improves the estimation of polygenic risk scores for breast cancer.

Journal of human genetics Oct 2, 2020
Polygenic risk scores (PRS) estimate the genetic risk of an individual for a complex disease based on many genetic variants across the whole genome. In this study, we compared a series of computational models for estimation of breast cancer PRS. A de...
Biomarkers, Tumor Case-Control Studies Genome-Wide Association Study ROC Curve Genetic Predisposition to Disease Polymorphism, Single Nucleotide Multifactorial Inheritance Phenotype Female Risk Factors Humans Breast Neoplasms Neural Networks, Computer Algorithms
View on PubMed DOI

Genome-wide association study-based deep learning for survival prediction.

Statistics in medicine Sep 24, 2020
Informative and accurate survival prediction with individualized dynamic risk profiles over time is critical for personalized disease prevention and clinical management. The massive genetic data, such as SNPs from genome-wide association studies (GWA...
Neural Networks, Computer Genome-Wide Association Study Machine Learning Polymorphism, Single Nucleotide Deep Learning
View on PubMed DOI

Evaluating the informativeness of deep learning annotations for human complex diseases.

Nature communications Sep 17, 2020
Deep learning models have shown great promise in predicting regulatory effects from DNA sequence, but their informativeness for human complex diseases is not fully understood. Here, we evaluate genome-wide SNP annotations from two previous deep learn...
Linkage Disequilibrium Deep Learning Disease Humans Polymorphism, Single Nucleotide Phenotype Genome-Wide Association Study Molecular Sequence Annotation Models, Genetic Histones Genetic Predisposition to Disease Alleles Genome, Human
View on PubMed DOI
Popular Topics
Recent Journals