AIMC Topic: Hepacivirus

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Clinical prediction of HBV and HCV related hepatic fibrosis using machine learning.

EBioMedicine Aug 10, 2018
Clinical prediction of advanced hepatic fibrosis (HF) and cirrhosis has long been challenging due to the gold standard, liver biopsy, being an invasive approach with certain limitations. Less invasive blood test tandem with a cutting-edge machine lea...
Liver Cirrhosis Area Under Curve Humans Internet Machine Learning Models, Biological Female Hepacivirus Reproducibility of Results Adult Male Middle Aged Cohort Studies ROC Curve Hepatitis B virus
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Intelligent Network DisRuption Analysis (INDRA): A targeted strategy for efficient interruption of hepatitis C transmissions.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases May 31, 2018
Hepatitis C virus (HCV) infection is a global public health problem. The implementation of public health interventions (PHI) to control HCV infection could effectively interrupt HCV transmission. PHI targeting high-risk populations, e.g., people who ...
Hepacivirus Indiana Humans HIV Infections Hepatitis C Incidence Contact Tracing Neural Networks, Computer Coinfection Substance Abuse, Intravenous HIV Universal Precautions
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HCV nonstructural protein 4 is associated with aggressiveness features of breast cancer.

Breast cancer (Tokyo, Japan) Dec 28, 2017
BACKGROUND: Hepatitis C virus (HCV) has the lymphotropic feature that is supposed to be the reason of related extrahepatic manifestation. HCV viral oncoproteins may participate in the regulation of some gene expression that has been implicated in tum...
Egypt Female Humans Hepatitis C Disease Progression Neoplasm Staging Aged Viral Nonstructural Proteins Incidence Neoplasm Grading Adult Mucin-1 Gene Expression Regulation, Neoplastic Breast Neoplasms Fibronectins Hepatitis C Antibodies Middle Aged Enzyme-Linked Immunosorbent Assay Hepacivirus Carcinogenesis
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Identification of recent cases of hepatitis C virus infection using physical-chemical properties of hypervariable region 1 and a radial basis function neural network classifier.

BMC genomics Dec 6, 2017
BACKGROUND: Identification of acute or recent hepatitis C virus (HCV) infections is important for detecting outbreaks and devising timely public health interventions for interruption of transmission. Epidemiological investigations and chemistry-based...
Humans Neural Networks, Computer Computational Biology Hepacivirus Hepatitis C Chemical Phenomena Viral Proteins
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QSAR studies of the bioactivity of hepatitis C virus (HCV) NS3/4A protease inhibitors by multiple linear regression (MLR) and support vector machine (SVM).

Bioorganic & medicinal chemistry letters May 3, 2017
In this study, quantitative structure-activity relationship (QSAR) models using various descriptor sets and training/test set selection methods were explored to predict the bioactivity of hepatitis C virus (HCV) NS3/4A protease inhibitors by using a ...
Antiviral Agents Support Vector Machine Dose-Response Relationship, Drug Molecular Structure Protease Inhibitors Hepacivirus Linear Models Serine Proteases Quantitative Structure-Activity Relationship Viral Nonstructural Proteins
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An improved method for predicting interactions between virus and human proteins.

Journal of bioinformatics and computational biology Jul 10, 2016
The interaction of virus proteins with host proteins plays a key role in viral infection and consequent pathogenesis. Many computational methods have been proposed to predict protein-protein interactions (PPIs), but most of the computational methods ...
Alphapapillomavirus Hepacivirus Host-Pathogen Interactions Gene Ontology Viral Proteins Protein Interaction Mapping Humans Reproducibility of Results Computational Biology Support Vector Machine Databases, Protein Amino Acids
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin for chronic hepatitis C virus genotype 4 infection in Egyptian patients with or without compensated cirrhosis (AGATE-II): a multicentre, phase 3, partly randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: In Egypt, chronic hepatitis C virus (HCV) infection occurs in around 10% of the population (about 8 million individuals), and is a leading cause of liver cirrhosis, hepatocellular carcinoma, and mortality. Although HCV genotype 4 constitu...
Sulfonamides Hepacivirus Administration, Oral Proline Ritonavir Drug Therapy, Combination Hepatitis C, Chronic Valine Drug Administration Schedule Anilides Liver Cirrhosis Treatment Outcome Follow-Up Studies Cyclopropanes Egypt Male Female Middle Aged Aged Adolescent Aged, 80 and over Antiviral Agents Carbamates Young Adult Humans Genotype Lactams, Macrocyclic Adult Macrocyclic Compounds Ribavirin Sustained Virologic Response
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin in adults with hepatitis C virus genotype 4 infection and cirrhosis (AGATE-I): a multicentre, phase 3, randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: Hepatitis C virus (HCV) genotype 4 infection is most commonly reported in sub-Saharan Africa and the Middle East; however, prevalence is increasing worldwide through immigration. HCV genotype 4 accounts for 20% of all infections, but clin...
Lactams, Macrocyclic Macrocyclic Compounds Ribavirin Sustained Virologic Response Hepatitis C, Chronic Valine Drug Administration Schedule Anilides Carbamates Hepacivirus Proline Ritonavir Drug Therapy, Combination Adult Humans Genotype Male Female Treatment Outcome Middle Aged Aged Follow-Up Studies Adolescent Aged, 80 and over Cyclopropanes Antiviral Agents Young Adult Sulfonamides
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Hepatitis C Virus Saint Petersburg Variant Detection With Machine Learning Methods.

Journal of medical virology Feb 1, 2025
Hepatitis C virus infection is a significant global health concern, affecting millions worldwide. Although direct-acting antivirals achieve over 90% success rate, treatment failures still occur, particularly when pan-genotypic DAAs are unavailable, a...
Genetic Variation Genotyping Techniques Viral Nonstructural Proteins Russia Molecular Epidemiology Humans Machine Learning Genotype Hepacivirus Hepatitis C
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Chronic kidney disease in Hepatitis C and its association with liver cirrhosis and viral load: Revealing the importance of hematuria.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia Jan 1, 2021
Hepatitis C virus (HCV) contributed as a risk factor for chronic kidney disease (CKD). Many studies only showed it associated with estimated glomerular filtration rate (eGFR) reduction and albuminuria, but none revealed hematuria data. Besides, liver...
Albuminuria Hepacivirus Hepatitis C Hematuria Male Humans Viral Load Female Liver Cirrhosis Risk Factors Renal Insufficiency, Chronic Cross-Sectional Studies Glomerular Filtration Rate
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