AIMC Topic: Humans

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Nanosensor-Based Pattern-Generating Probe Accelerates Sepsis Diagnosis.

ACS nano
Biomimetic optical sensor arrays hold promising potential in differentiating nuances within intricate mixtures and biosamples. Nonetheless, developing a standalone pattern-generating sensor for multianalyte identification in clinical biofluids, witho...

The association between estimated glucose disposal rate and the prevalence and mortality of chronic kidney disease: a cross-sectional study with linked mortality follow-up.

European journal of medical research
BACKGROUND: Metabolic disorders represented by insulin resistance (IR) are at risk of chronic kidney disease (CKD). Estimated glucose disposal rate (eGDR) reflects IR. The relationship between eGDR and CKD was unclear. This study aimed at discussing ...

Identification of ferroptosis- and mitochondrial metabolism-related biomarkers and the potential molecular mechanisms of poor ovarian response.

Journal of ovarian research
BACKGROUND: Ferroptosis and mitochondrial metabolism are closely associated with the pathological processes of various diseases. However, the role of ferroptosis-related genes (FRGs) and mitochondrial metabolism-related genes (MMRGs) in poor ovarian ...

Machine learning-based screening and validation of pyroptosis-associated prognostic genes and potential drugs in cervical cancer.

BMC medical genomics
Pyroptosis is a newly discovered form of programmed cell death, but its mechanism in the development of cervical cancer has not been elucidated. Cervical cancer differentially expressed pyroptosis-related genes were identified via bioinformatic analy...

Precision integrated identification of predictive first-trimester metabolomics signatures for early detection of gestational diabetes mellitus.

Cardiovascular diabetology
BACKGROUND AND AIM: Gestational diabetes mellitus (GDM), a common pregnancy-related metabolic disorder, often goes undiagnosed until the second trimester, limiting early intervention opportunities. Given the higher prevalence of GDM in India, there i...

Development of a consensus molecular classifier for pancreatic ductal adenocarcinoma.

Genome medicine
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) presents a significant challenge, with a 5-year survival rate of approximately 10%. Tumor heterogeneity contributes to the limited effectiveness of treatments. Several tumor and stroma molecular cla...

Precision medicine exploration of postpartum rectus abdominis muscle separation: from basic research to clinical practice.

BMC surgery
Postpartum diastasis recti abdominis (PDRA), characterized by pathological separation of the rectus abdominis muscles, affects 30%-60% of women, with many cases persisting beyond 6 months postpartum and having significant impacts on musculoskeletal f...

Artificial intelligence-driven kidney organ allocation: systematic review of clinical outcome prediction, ethical frameworks, and decision-making algorithms.

BMC nephrology
Kidney transplantation remains the optimal treatment for end-stage renal disease, yet persistent organ shortages and inequitable allocation necessitate innovative solutions. Artificial intelligence (AI) and machine learning (ML) have emerged as promi...

Prediction of uterine cavity conception environment using two-dimensional transvaginal ultrasound imaging semantic feature-based machine learning: a case-control study.

BMC pregnancy and childbirth
BACKGROUND: Independently investigating the association between pregnancy outcomes and the uterine cavity conception environment (UCCE) is challenging. Therefore, this study aimed to employ a range of machine learning algorithms to systematically ana...

Explainable machine learning for predicting clinical outcomes in HIV/TB co-infection: a comparative retrospective study.

BMC infectious diseases
BACKGROUND: HIV/TB co-infection presents substantial public-health challenges, showing greater treatment-failure and mortality rates than tuberculosis alone. Recent advances in machine learning (ML) provide a robust means of identifying high-risk pat...