AIMC Topic: Humans

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Targeting CXCL8 in post-traumatic stress disorder and Alzheimer's disease: insights from cross-disorder molecular analysis.

Annals of medicine
BACKGROUND: Emerging clinical evidence indicates that post-traumatic stress disorder (PTSD) may accelerate Alzheimer's disease progression, yet the molecular mechanisms linking these disorders remain poorly understood.

Primate-informed neural network for visual decision-making.

Proceedings of the National Academy of Sciences of the United States of America
The human brain excels at complex tasks with remarkable efficiency, adaptability, and resilience, making it a powerful source of inspiration for AI. Here, we present a neural dynamics model inspired by the primate dorsal visual pathway, a circuit cru...

Machine learning-based integration of tumor deposit molecular signatures improves prognostic stratification in colon adenocarcinoma.

International journal of colorectal disease
BACKGROUND: Colon adenocarcinoma (COAD) remains a leading cause of cancer-related mortality worldwide. Although tumor deposits (TDs) are established prognostic indicators, their molecular characteristics and potential for improving risk stratificatio...

Implementing QbD for Nano-Pharmaceuticals and Complex Formulations to Achieve Predictable and High-Quality Outcomes.

AAPS PharmSciTech
Recent advances in artificial intelligence (AI) and machine learning (ML) are revolutionizing nanopharmaceutical development by enabling data-driven formulation design, process optimization, and prediction of biological performance. AI encompasses co...

An interpretable machine learning model based on MRI radiomics and GAME score for predicting early recurrence after thermal ablation in colorectal liver metastases.

International journal of colorectal disease
OBJECTIVE: To develop and validate machine learning models based on preoperative magnetic resonance imaging(MRI) and baseline clinical characteristics for predicting early recurrence(ER) in patients with colorectal liver metastases(CRLM) treated with...

Ensemble deep learning architectures for detecting pulmonary tuberculosis in chest X-rays.

Scientific reports
Tuberculosis (TB) remains a major global health challenge, causing approximately 1.4 million deaths annually. In many high-burden regions, limited access to expert radiological interpretation leads to delayed or missed diagnoses. To address this, we ...

Advancing adoptive T cell therapy in ovarian cancer: barriers, innovations, and emerging platforms.

Journal for immunotherapy of cancer
Adoptive cell therapy (ACT) has demonstrated curative potential in select cancers, but its translation to solid tumors such as ovarian cancer (OC) has been hindered by multiple factors, including tumor heterogeneity, immune exclusion, and a profoundl...

Early Prediction of Cardiac Arrest Based on Time-Series Vital Signs Using Deep Learning: Retrospective Study.

JMIR formative research
BACKGROUND: Cardiac arrest (CA), characterized by an extremely high mortality rate, remains one of the most pressing global public health challenges. It not only causes a substantial strain on health care systems but also severely impacts individual ...

Physical Activity Recommendations Tailored by a Predictive Model for Adults With High Blood Pressure: Observational Study.

Journal of medical Internet research
BACKGROUND: Whether the benefits of identical physical activity (PA) patterns for adults with high blood pressure (BP) vary according to an individual's characteristics has not been adequately studied.