AIMC Topic: Humans

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An interpretable machine learning model predicts the interactive and cumulative risks of different environmental chemical exposures on depression.

Translational psychiatry
Humans are exposed to a multitude of environmental chemical mixtures (ECMs) in daily life that may influence depression risk. While prior studies have shown individual ECM exposures to depression, the cumulative and interactive effects of multiple co...

ClairS-TO: a deep-learning method for long-read tumor-only somatic small variant calling.

Nature communications
Accurate detection of somatic variants in tumors is of critical importance and remains challenging. Current methods typically require matched normal samples for reliable detection, which are often unavailable in real-world research and clinical scena...

Optic disc morphometrics as a potential ocular biomarker for depression: evidence from two cross-sectional cohort studies.

Translational psychiatry
Depression, which is increasingly prevalent among older adults, has traditionally been diagnosed through symptom-based questionnaires. However, emerging evidence suggests that retinal changes could serve as objective biomarkers for depression. In thi...

The application of amplitude of low-frequency fluctuations metrics in the diagnosis and prediction of treatment response as well as their associated genes and biological processes in patients with bipolar disorder.

Translational psychiatry
While previous studies have reported functional abnormalities in the prefrontal-limbic-subcortical circuit, the treatment effects on this activity remain unclear. This longitudinal study aimed to investigate spontaneous brain activity in bipolar diso...

Comparative study of coronary artery disease prediction: conventional QRISK3 versus enhanced machine learning models combined with particle swarm optimisation algorithm.

Open heart
BACKGROUND: Coronary artery disease (CAD) is one of the biggest causes of mortality worldwide. Risk stratification for early detection is essential for the primary prevention of CAD. QRISK3 is known to overestimate future CAD risk in some populations...

Artificial intelligence capabilities in identifying atrial fibrillation using baseline sinus rhythm ECG : a systematic review.

Open heart
BACKGROUND: Atrial fibrillation (AF) is a prevalent arrhythmia associated with adverse outcomes, often presenting paroxysmally. The lack of an efficient method to promptly detect paroxysmal AF and the absence of a unified screening approach necessita...

Artificial intelligence-powered spatial analysis of tumor microenvironment in patients with non-small cell lung cancer with acquired resistance to EGFR tyrosine kinase inhibitor.

Journal for immunotherapy of cancer
PURPOSE: This study evaluated the dynamic changes in the tumor microenvironment (TME) in patients with non-small cell lung cancer (NSCLC) and acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) using an ar...

Wearable Artificial Intelligence for Epilepsy: Scoping Review.

Journal of medical Internet research
BACKGROUND: Epilepsy affects approximately 50 million people globally and imposes a substantial clinical and societal burden, requiring continuous and personalized monitoring for effective management. Wearable artificial intelligence (AI) technologie...

Governing AI in Mental Health: 50-State Legislative Review.

JMIR mental health
BACKGROUND: Mental health-related artificial intelligence (MH-AI) systems are proliferating across consumer and clinical contexts, outpacing regulatory frameworks and raising urgent questions about safety, accountability, and clinical integration. Re...

Implementation, Experiences, Impact, and Costs of Artificial Intelligence in Chest Diagnostics: Protocol for a Mixed Methods Evaluation.

JMIR research protocols
BACKGROUND: The ability to perform complex tasks has seen artificial intelligence (AI) used to support radiology in clinical settings, including lung cancer detection and diagnosis. Evidence suggests that AI can contribute to accurate diagnosis, redu...