AIMC Topic: Humans

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PGxO and PGxLOD: a reconciliation of pharmacogenomic knowledge of various provenances, enabling further comparison.

BMC bioinformatics Apr 18, 2019
BACKGROUND: Pharmacogenomics (PGx) studies how genomic variations impact variations in drug response phenotypes. Knowledge in pharmacogenomics is typically composed of units that have the form of ternary relationships gene variant - drug - adverse ev...
Tissue Banks Pharmacogenetics Knowledge Bases Data Mining Humans Databases, Factual Electronic Health Records
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Applications of machine learning in GPCR bioactive ligand discovery.

Current opinion in structural biology Apr 18, 2019
GPCRs constitute the largest druggable family having targets for 475 Food and Drug Administration (FDA) approved drugs. As GPCRs are of great interest to pharmaceutical industry, enormous efforts are being expended to find relevant and potent GPCR li...
Machine Learning Humans Receptors, G-Protein-Coupled Drug Design Drug Discovery Ligands
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SPINDLE: End-to-end learning from EEG/EMG to extrapolate animal sleep scoring across experimental settings, labs and species.

PLoS computational biology Apr 18, 2019
Understanding sleep and its perturbation by environment, mutation, or medication remains a central problem in biomedical research. Its examination in animal models rests on brain state analysis via classification of electroencephalographic (EEG) sign...
Signal Processing, Computer-Assisted Electromyography Wakefulness Computational Biology Rats Electroencephalography Sleep Models, Animal Humans Neural Networks, Computer Machine Learning Animals Mice
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Diagnosis of pain in the right iliac fossa. A new diagnostic score based on Decision-Tree and Artificial Neural Network Methods.

Cirugia espanola Apr 18, 2019
INTRODUCTION: Pain in the right iliac fossa (RIF) continues to pose diagnostic challenges. The objective of this study is the development of a RIF pain diagnosis model based on classification trees of type CHAID (Chi-Square Automatic Interaction Dete...
Male Middle Aged Inflammation Pain Measurement Appendicitis Decision Trees Diagnosis, Differential Female Reproducibility of Results Adult Abdominal Pain Ilium Humans Neural Networks, Computer
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Artificial Intelligence and Optical Coherence Tomography Imaging.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) Apr 18, 2019
This review article aimed to highlight the application and use of artificial intelligence (AI) in optical coherence tomography (OCT) imaging in ophthalmology. Artificial intelligence programs seek to simulate intelligent human behavior in computers. ...
Ophthalmology Humans Eye Diseases Artificial Intelligence Tomography, Optical Coherence
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Coverage of ethics within the artificial intelligence and machine learning academic literature: The case of disabled people.

Assistive technology : the official journal of RESNA Apr 17, 2019
Disabled people are often the anticipated users of scientific and technological products and processes advanced and enabled by artificial intelligence (AI) and machine learning (ML). Disabled people are also impacted by societal impacts of AI/ML. Man...
Machine Learning Humans Artificial Intelligence
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Open-source pipeline for multi-class segmentation of the spinal cord with deep learning.

Magnetic resonance imaging Apr 17, 2019
This paper presents an open-source pipeline to train neural networks to segment structures of interest from MRI data. The pipeline is tailored towards homogeneous datasets and requires relatively low amounts of manual segmentations (few dozen, or les...
Image Processing, Computer-Assisted Magnetic Resonance Imaging Spinal Cord White Matter Callithrix Neural Networks, Computer Gray Matter Humans Animals Models, Animal Deep Learning
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Predictive Estimates of Risks Associated with Type 2 Diabetes Mellitus on the Basis of Biochemical Biomarkers and Derived Time-Dependent Parameters.

Journal of computational biology : a journal of computational molecular cell biology Apr 17, 2019
Female Risk Factors Male Machine Learning Biomarkers Prognosis Diabetes Mellitus, Type 2 Cholesterol Alanine Transaminase Aspartate Aminotransferases Humans Risk Assessment Big Data Blood Glucose
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New Multiparametric Analysis of Cardiac Dyssynchrony: Machine Learning and Prediction of Response to CRT.

JACC. Cardiovascular imaging Apr 17, 2019
Image Interpretation, Computer-Assisted Clinical Decision-Making Ventricular Function, Left Echocardiography Humans Electrocardiography Machine Learning Signal Processing, Computer-Assisted Cardiac Resynchronization Therapy Treatment Outcome Decision Support Techniques Heart Failure Ventricular Dysfunction, Left Predictive Value of Tests Retrospective Studies
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Toward an Expert Level of Lung Cancer Detection and Classification Using a Deep Convolutional Neural Network.

The oncologist Apr 17, 2019
BACKGROUND: Computed tomography (CT) is essential for pulmonary nodule detection in diagnosing lung cancer. As deep learning algorithms have recently been regarded as a promising technique in medical fields, we attempt to integrate a well-trained dee...
Neural Networks, Computer Algorithms Databases, Factual Retrospective Studies Humans ROC Curve Lung Neoplasms Radiographic Image Interpretation, Computer-Assisted Middle Aged Lung Deep Learning Tomography, X-Ray Computed Female Male
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