AIMC Topic: Immune Checkpoint Inhibitors
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Analysis of Tumor Microenvironment Characteristics in Bladder Cancer: Implications for Immune Checkpoint Inhibitor Therapy.
Frontiers in immunology
Apr 15, 2021
The tumor microenvironment (TME) plays a crucial role in cancer progression and recent evidence has clarified its clinical significance in predicting outcomes and efficacy. However, there are no studies on the systematic analysis of TME characteristi...
Assessing PD-L1 expression in non-small cell lung cancer and predicting responses to immune checkpoint inhibitors using deep learning on computed tomography images.
Theranostics
Jan 1, 2021
This study aimed to use computed tomography (CT) images to assess PD-L1 expression in non-small cell lung cancer (NSCLC) and predict response to immunotherapy. We retrospectively analyzed a PD-L1 expression dataset that consisted of 939 consecutive...
Using Machine Learning Algorithms to Predict Immunotherapy Response in Patients with Advanced Melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Nov 18, 2020
PURPOSE: Several biomarkers of response to immune checkpoint inhibitors (ICI) show potential but are not yet scalable to the clinic. We developed a pipeline that integrates deep learning on histology specimens with clinical data to predict ICI respon...
Middle Aged
Risk Assessment
Disease Progression
ROC Curve
Immune Checkpoint Inhibitors
Skin Neoplasms
Aged
Adult
Male
Progression-Free Survival
Drug Resistance, Neoplasm
Image Processing, Computer-Assisted
Follow-Up Studies
Neoplasm Staging
Skin
Humans
Machine Learning
Prospective Studies
Prognosis
Female
Melanoma
Biomarkers of the Response to Immune Checkpoint Inhibitors in Metastatic Urothelial Carcinoma.
Frontiers in immunology
Aug 25, 2020
The mechanisms underlying the resistance to immune checkpoint inhibitors (ICIs) therapy in metastatic urothelial carcinoma (mUC) patients are not clear. It is of great significance to discern mUC patients who could benefit from ICI therapy in clinica...
Carcinoma
Drug Resistance, Neoplasm
Urothelium
Treatment Outcome
Antibodies, Monoclonal, Humanized
Urinary Bladder Neoplasms
Predictive Value of Tests
Time Factors
Immune Checkpoint Inhibitors
B7-H1 Antigen
Humans
Nomograms
Machine Learning
Biomarkers, Tumor
Male
Risk Assessment
Gene Expression Profiling
Transcriptome
Decision Support Techniques
Clinical Decision-Making
Female
Risk Factors
Radiomics can predict tumour response in patients treated with Nivolumab for a metastatic renal cell carcinoma: an artificial intelligence concept.
World journal of urology
Jul 6, 2020
Combination Strategies for Immune-Checkpoint Blockade and Response Prediction by Artificial Intelligence.
International journal of molecular sciences
Apr 19, 2020
The therapeutic concept of unleashing a pre-existing immune response against the tumor by the application of immune-checkpoint inhibitors (ICI) has resulted in long-term survival in advanced cancer patient subgroups. However, the majority of patients...
Novel approaches for glioblastoma treatment: Focus on tumor heterogeneity, treatment resistance, and computational tools.
Cancer reports (Hoboken, N.J.)
Nov 11, 2019
BACKGROUND: Glioblastoma (GBM) is a highly aggressive primary brain tumor. Currently, the suggested line of action is the surgical resection followed by radiotherapy and treatment with the adjuvant temozolomide, a DNA alkylating agent. However, the a...
Microtubules
Tumor Suppressor Protein p53
Tumor Suppressor Proteins
DNA Modification Methylases
DNA Mutational Analysis
DNA Repair Enzymes
Drug Resistance, Neoplasm
Glioblastoma
Computational Biology
Prognosis
Mutation
Humans
Cancer Vaccines
Tumor Microenvironment
Genetic Heterogeneity
Machine Learning
Brain Neoplasms
Chemoradiotherapy, Adjuvant
Brain
Models, Genetic
Clonal Evolution
Precision Medicine
Immune Checkpoint Inhibitors
Antineoplastic Combined Chemotherapy Protocols
Tumor-Intrinsic and Microenvironmental Determinants of Impaired Antitumor Immunity in Chromophobe Renal Cell Carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Aug 10, 2025
PURPOSE: While immune checkpoint inhibition (ICI) has transformed the management of many advanced renal cell carcinomas (RCCs), the determinants of effective antitumor immunity for chromophobe RCC (ChRCC) and renal oncocytic tumors remain an unmet cl...
[Progress in neoadjuvant immunotherapy for locally advanced rectal cancer].
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
Jun 25, 2025
Neoadjuvant chemoradiotherapy (NACRT) is the standard treatment for locally advanced rectal cancer (LARC), yet the pathological complete response (pCR) rates remain suboptimal. The introduction of immunotherapy has opened new avenues for LARC managem...
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