AIMC Topic: Immunosuppressive Agents
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Advancing patient monitoring, diagnostics, and treatment strategies for transplant precision medicine.
Lancet (London, England)
Jul 1, 2025
Transplant medicine faces substantial challenges, as patients require lifelong immunosuppression to prevent graft rejection. Immunosuppressive regimens to date, while reasonably effective at preventing acute rejection, cause numerous health complicat...
Comparison of Machine Learning Algorithms and Bayesian Estimation in Predicting Tacrolimus Concentration in Tunisian Kidney Transplant Patients During the Early Post-Transplant Period.
European journal of drug metabolism and pharmacokinetics
May 8, 2025
BACKGROUND AND OBJECTIVE: Model-informed precision dosing (MIPD), based on a Bayesian approach and machine learning (ML) algorithms, is a suitable approach to personalize dosage recommendations and to improve the concentration target attainment for e...
Pancreas rejection: quieting the storm to preserve graft function.
Current opinion in organ transplantation
Apr 23, 2025
PURPOSE OF REVIEW: Allograft rejection remains enigmatic and elusive following pancreas transplantation. In the absence of early technical pancreas graft failure, pancreas allograft rejection is the major cause of death-censored pancreas graft loss b...
Advancing lung transplantation through machine learning and artificial intelligence.
Current opinion in pulmonary medicine
Apr 21, 2025
PURPOSE OF REVIEW: To explore the current applications of artificial intelligence and machine learning in lung transplantation, including outcome prediction, drug dosing, and the potential future uses and risks as the technology continues to evolve.
ShenJiaoLingCao decoction ameliorates cyclophosphamide-induced splenic injury and immunosuppression via the inhibition of MEK/ERK signaling pathway activity and modulation of amino acid metabolism.
Journal of ethnopharmacology
Apr 16, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: ShenJiaoLingCao Decoction (SJLCD) is derived from the classic Chinese medicine prescription, which consists of ten kinds of herbs. In China, SJLCD has been used as an immunomodulator in clinical practice for more than ...
Multi-stain deep learning prediction model of treatment response in lupus nephritis based on renal histopathology.
Kidney international
Dec 27, 2024
The response of the kidney after induction treatment is one of the determinants of prognosis in lupus nephritis, but effective predictive tools are lacking. Here, we sought to apply deep learning approaches on kidney biopsies for treatment response p...
Clinicopathological features for the prediction of immunosuppressive treatment responses in sarcoidosis-related kidney involvement: a single-center retrospective study.
Turkish journal of medical sciences
Oct 8, 2024
BACKGROUND/AIM: Sarcoidosis is a multisystem disorder that affects many organs, including the kidneys. This single-center retrospective study investigated the clinical, pathological, and laboratory findings of patients with kidney sarcoidosis who wer...
Machine-learning model to predict the tacrolimus concentration and suggest optimal dose in liver transplantation recipients: a multicenter retrospective cohort study.
Scientific reports
Aug 28, 2024
Titrating tacrolimus concentration in liver transplantation recipients remains a challenge in the early post-transplant period. This multicenter retrospective cohort study aimed to develop and validate a machine-learning algorithm to predict tacrolim...
Using machine learning to classify the immunosuppressive activity of per- and polyfluoroalkyl substances.
Toxicology mechanisms and methods
Aug 5, 2024
Per- and polyfluoroalkyl substances (PFASs), one of the persistent organic pollutants, have immunosuppressive effects. The evaluation of this effect has been the focus of regulatory toxicology. In this investigation, 146 PFASs (immunosuppressive or n...
Optimizing post-transplantation outcomes: the role of multi-omics, artificial intelligence, and animal models in addressing immunosuppression-associated hepatotoxicity.
International journal of surgery (London, England)
Aug 1, 2024
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