AIMC Topic: Indoles
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Colony analysis and deep learning uncover 5-hydroxyindole as an inhibitor of gliding motility and iridescence in Cellulophaga lytica.
Microbiology (Reading, England)
Feb 5, 2018
Iridescence is an original type of colouration that is relatively widespread in nature but has been either incompletely described or entirely neglected in prokaryotes. Recently, we reported a brilliant 'pointillistic' iridescence in agar-grown colony...
From word models to executable models of signaling networks using automated assembly.
Molecular systems biology
Nov 24, 2017
Word models (natural language descriptions of molecular mechanisms) are a common currency in spoken and written communication in biomedicine but are of limited use in predicting the behavior of complex biological networks. We present an approach to b...
Skin Neoplasms
Antineoplastic Agents
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Neural Networks, Computer
Computer Simulation
Language
Melanoma
Sulfonamides
Indoles
Enzyme Inhibitors
Drug Resistance, Neoplasm
Models, Genetic
Signal Transduction
Natural Language Processing
DNA Damage
Humans
Tumor Suppressor Protein p53
Proto-Oncogene Proteins p21(ras)
Proto-Oncogene Proteins B-raf
Vemurafenib
COF-1-modified magnetic nanoparticles for highly selective and efficient solid-phase microextraction of paclitaxel.
Talanta
Dec 21, 2016
Novel covalent organic framework-1 modified magnetic nanoparticles (M-COF-1) were prepared for extraction of paclitaxel from rat plasma samples. Paclitaxel is an important anti-cancer drug in clinical chemotherapy. COF-1 was immobilized on the surfac...
Enhanced photostability, radical scavenging and antitumor activity of indole-3-carbinol-loaded rose hip oil nanocapsules.
Materials science & engineering. C, Materials for biological applications
Dec 14, 2016
This study aimed to develop poly(ε-caprolactone) nanocapsules loaded with indole-3-cabinol (I3C) using rose hip oil (RHO) or medium chain triglycerides (MCT) as oil core. In vitro radical scavenging activity (DPPH method), hemolysis, and antitumor ef...
Polydopamine-assisted partial hydrolyzed poly(2-methyl-2-oxazolinze) as coating for determination of melamine in milk by capillary electrophoresis.
Talanta
Dec 21, 2015
Nitrogen-rich melamine (66% by mass) had been found to be illegally adulterated to milk products and animal feed in order to increase the apparent protein content, and ingestion of melamine may lead to the formation of kidney stones. Hence, the devel...
PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues - A population pharmacokinetic/pharmacodynamic analysis of rucaparib.
Clinical pharmacology in drug development
Jan 26, 2015
PURPOSE: Rucaparib is a potent Poly (ADP-ribose) Polymerase (PARP) inhibitor currently under clinical development. The objectives of this analysis were to establish population PK and PK/PD models for rucaparib, and to evaluate the predictability of P...
Deep learning for in vivo near-infrared imaging.
Proceedings of the National Academy of Sciences of the United States of America
Jan 5, 2021
Detecting fluorescence in the second near-infrared window (NIR-II) up to ∼1,700 nm has emerged as a novel in vivo imaging modality with high spatial and temporal resolution through millimeter tissue depths. Imaging in the NIR-IIb window (1,500-1,700 ...
Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures.
Acta pharmaceutica (Zagreb, Croatia)
Dec 20, 2017
Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate deriva...
Silica Cross-Linked Micellar Core--Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo.
Journal of biomedical nanotechnology
Feb 1, 2017
IR-780 iodide, a near-infrared (NIR) fluorescent heptamethine dye, has attracted wide attention in the biomedical community. However, hydrophobicity and toxicity severely limit its further biomedical application. Although many successful efforts have...
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