AIMC Topic: Inflammation
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Targeted metabolomics reveals bioactive inflammatory mediators from gut into blood circulation in children with NAFLD.
NPJ biofilms and microbiomes
Jul 1, 2025
Altered gut metabolites are important for the inflammatory progression in children with NAFLD. Fecal and plasma samples were collected from 145 subjects including 53 non-alcoholic fatty liver (NAFL), 39 nonalcoholic steatohepatitis (NASH) and 53 obes...
Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease.
Cardiovascular diabetology
Jun 23, 2025
BACKGROUND: Coronary angiography remains the gold standard for diagnosing coronary artery disease (CAD), but its invasive nature limits its applicability for widespread screening. Identifying non-invasive molecular markers could improve CAD classific...
5-Methylcytosine
Predictive Value of Tests
ST Elevation Myocardial Infarction
Coronary Artery Disease
Inflammation Mediators
Male
Middle Aged
Risk Assessment
Severity of Illness Index
Biomarkers
Epigenesis, Genetic
Prognosis
Humans
Inflammation
Female
Machine Learning
DNA Methylation
Reproducibility of Results
Cell-Free Nucleic Acids
Aged
Non-ST Elevated Myocardial Infarction
Machine learning based gut microbiota pattern and response to fiber as a diagnostic tool for chronic inflammatory diseases.
BMC microbiology
Jun 6, 2025
Gut microbiota has been implicated in the pathogenesis of multiple gastrointestinal (GI) and systemic metabolic and inflammatory disorders where disrupted gut microbiota composition and function (dysbiosis) has been found in multiple studies. Thus, h...
Harnessing vaginal inflammation and microbiome: a machine learning model for predicting IVF success.
NPJ biofilms and microbiomes
Jun 5, 2025
Humans are the only species with a commensal Lactobacillus-dominant vaginal microbiota. Reproductive tract microbes have been linked to fertility outcomes, as has intrauterine inflammation, suggesting immune response may mediate adverse outcomes. In ...
Integrative machine learning identifies robust inflammation-related diagnostic biomarkers and stratifies immune-heterogeneous subtypes in Kawasaki disease.
Pediatric rheumatology online journal
Jun 2, 2025
BACKGROUND: Kawasaki disease (KD), a pediatric systemic vasculitis, lacks reliable diagnostic biomarkers and exhibits immune heterogeneity, complicating clinical management. Current therapies face challenges in targeting specific immune pathways and ...
Divergent Immune Pathways in Coronary Artery Disease and Aortic Stenosis: The Role of Chronic Inflammation and Senescence.
International journal of molecular sciences
May 29, 2025
Coronary artery disease (CAD) remains a major cause of cardiovascular morbidity and mortality, with growing evidence linking immune dysregulation to its pathogenesis. Aortic stenosis often coexists with CAD (ASCAD), representing an advanced disease f...
Inflammatory biomarkers as predictors for unlocking antidepressant efficacy: Assessing predictive value and risk stratification in major depressive disorder in a prospective longitudinal study.
Journal of affective disorders
May 28, 2025
BACKGROUND: Major depressive disorder (MDD) is characterized by significant heterogeneity in treatment response, with inflammation hypothesized to play a role in its pathophysiology. Peripheral inflammatory biomarkers, such as the neutrophil-to-lymph...
Hemoglobin - to - red cell distribution width ratio in depression symptoms: Threshold effects and metabolic - inflammatory mediation revealed by multimodal machine learning and symptom network analysis in 196,260 adults.
Journal of affective disorders
May 27, 2025
OBJECTIVE: To investigate the association between hemoglobin to red blood cell distribution width ratio (HRR) and depression symptoms.
Altered aminoacid and lipid metabolism in a rat orofacial inflammation model determined by omics approach: potential role in trigeminal sensitisation.
The journal of headache and pain
May 8, 2025
BACKGROUND: Trigeminal activation and sensitisation involved in chronic inflammatory orofacial pain share several similarities with headaches, including migraine. Therefore, understanding the pathophysiological mechanisms is important to determine no...
Systemic inflammation mediates the relationship between urinary cadmium and chronic cough risk: findings based on multiple statistical models.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
May 7, 2025
Epidemiological research examining the relationship between urinary cadmium and the risk of chronic cough remains scarce. This study included 2965 participants for a cross-sectional study from the NHANES. The weighted quantile sum (WQS) regression, b...
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