AIMC Topic: Inflammasomes

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Artificial intelligence-powered prediction of AIM-2 inflammasome sequences using transformers and graph attention networks in periodontal inflammation.

Scientific reports Mar 13, 2025
Periodontal inflammation is a chronic condition affecting the tissues surrounding teeth. Initiated by dental plaque, it triggers an immune response leading to tissue destruction. The AIM-2 inflammasome regulates this response, and understanding its p...
DNA-Binding Proteins Amino Acid Sequence Inflammasomes Humans Artificial Intelligence Inflammation
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Deep-Learning-Driven Discovery of SN3-1, a Potent NLRP3 Inhibitor with Therapeutic Potential for Inflammatory Diseases.

Journal of medicinal chemistry Sep 20, 2024
The NLRP3 inflammasome plays a central role in the pathogenesis of various intractable human diseases, making it an urgent target for therapeutic intervention. Here, we report the development of SN3-1, a novel orally potent NLRP3 inhibitor, designed ...
NLR Family, Pyrin Domain-Containing 3 Protein Humans Inflammasomes Animals Crystallography, X-Ray Male Inflammation Drug Discovery Mice, Inbred C57BL Deep Learning Structure-Activity Relationship Mice
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Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage.

Oxidative medicine and cellular longevity Dec 14, 2021
Existing treatments for intracerebral hemorrhage (ICH) are unable to satisfactorily prevent development of secondary brain injury after ICH and multiple pathological mechanisms are involved in the development of the injury. In this study, we aimed to...
Proteome Brain Injuries Animals Cerebral Hemorrhage Inflammasomes Humans Mice, Inbred C57BL Male Interleukin-12 Biomarkers Sphingolipids Collagenases Mice Prognosis
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Massively parallel unsupervised single-particle cryo-EM data clustering via statistical manifold learning.

PloS one Aug 7, 2017
Structural heterogeneity in single-particle cryo-electron microscopy (cryo-EM) data represents a major challenge for high-resolution structure determination. Unsupervised classification may serve as the first step in the assessment of structural hete...
Cryoelectron Microscopy Proteasome Endopeptidase Complex Ribosome Subunits, Large, Bacterial Principal Component Analysis Inflammasomes Multivariate Analysis Computer Simulation Imaging, Three-Dimensional Image Processing, Computer-Assisted Escherichia coli Cluster Analysis Unsupervised Machine Learning
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Repurposing FDA-approved drugs as NLRP3 inhibitors against inflammatory diseases: machine learning and molecular simulation approaches.

Journal of biomolecular structure & dynamics May 1, 2025
Activation of NLRP3 (NOD-like receptor family, pyrin domain-containing protein 3) has been associated with multiple chronic pathologies, including diabetes, atherosclerosis, and rheumatoid arthritis. Moreover, histone deacetylases (HDACs), specifical...
Protein Binding Inflammation United States Humans Machine Learning Molecular Docking Simulation Inflammasomes Drug Repositioning United States Food and Drug Administration NLR Family, Pyrin Domain-Containing 3 Protein Drug Approval Molecular Dynamics Simulation
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[Effects of acupuncture on Nod-like receptor protein 3 inflammasome signal pathway in the prefrontal cortex of rat with depression].

Zhen ci yan jiu = Acupuncture research Oct 25, 2020
OBJECTIVE: To observe the influence of acupuncture on the expression of pivotal molecules of Nod-like receptor protein 3(NLRP3) inflammasome signal pathway in the prefrontal cortex of rats with depression, so as to explore the underlying mechanism of...
Hippocampus Prefrontal Cortex Depression Rats NLR Proteins Signal Transduction Animals Inflammasomes Rats, Sprague-Dawley Acupuncture Therapy Interleukin-1beta
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[Sodium Ferulate Attenuates Oxidative Stressvia Suppressing NALP3 Inflammasome and ERK Signal Pathway].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Sep 1, 2016
OBJECTIVES: Study the gene and protein expression of NACHT-PYD-containing protein 3 (NALP3) inflammasome and extracellular regulated protein kinase (ERK), the intervention effects of sodium ferulate (SF) in human lung epithelial cells A549 under oxid...
Interleukin-1beta NLR Family, Pyrin Domain-Containing 3 Protein Inflammasomes MAP Kinase Signaling System Oxidative Stress Coumaric Acids Flavonoids Humans A549 Cells Hydrogen Peroxide
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[Role and mechanism of the NOD-like receptor 3 inflammasome in ventilator-induced lung injury in rats].

Zhonghua wei zhong bing ji jiu yi xue Oct 1, 2015
OBJECTIVE: To investigate the role and its mechanism of the NOD-like receptor 3 (NLRP3) inflammasome in alveolar macrophages in ventilator-induced lung injury (VILI) in rats.
Caspase 1 Macrophages, Alveolar Ventilator-Induced Lung Injury Inflammasomes Random Allocation Bronchoalveolar Lavage Fluid Carrier Proteins Tidal Volume Interleukin-1beta NF-kappa B Animals NLR Family, Pyrin Domain-Containing 3 Protein Interleukin-18 RNA, Messenger Rats Rats, Sprague-Dawley Male Respiration, Artificial Lung
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