AIMC Topic: Infusions, Intravenous
Clear Filters Showing 21 to 30 of 45 articles
Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients.
International journal of antimicrobial agents
Dec 22, 2017
Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models constructed with intermittent infusion data. However, the probability of targ...
Simplifying Piperacillin/Tazobactam Dosing: Pharmacodynamics of Utilizing Only 4.5 or 3.375 g Doses for Patients With Normal and Impaired Renal Function.
Journal of pharmacy practice
Dec 21, 2016
OBJECTIVES: To evaluate the pharmacodynamic exposure of piperacillin/tazobactam across the renal function range using 4.5 or 3.375 g dosing regimens.
Quantitative analysis of maytansinoid (DM1) in human serum by on-line solid phase extraction coupled with liquid chromatography tandem mass spectrometry - Method validation and its application to clinical samples.
Journal of pharmaceutical and biomedical analysis
Dec 22, 2015
A sensitive and specific method was developed and validated for the quantitation of maytansinoid (DM1) in human serum using on-line solid phase extraction (SPE)-liquid chromatography-tandem mass spectrometry (LC-MS/MS). Because DM1 contains a free th...
PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues - A population pharmacokinetic/pharmacodynamic analysis of rucaparib.
Clinical pharmacology in drug development
Jan 26, 2015
PURPOSE: Rucaparib is a potent Poly (ADP-ribose) Polymerase (PARP) inhibitor currently under clinical development. The objectives of this analysis were to establish population PK and PK/PD models for rucaparib, and to evaluate the predictability of P...
Absolute oral bioavailability and pharmacokinetics of canagliflozin: A microdose study in healthy participants.
Clinical pharmacology in drug development
Dec 11, 2014
Absolute oral bioavailability of canagliflozin was assessed by simultaneous oral administration with intravenous [(14) C]-canagliflozin microdose infusion in nine healthy men. Pharmacokinetics of canagliflozin, [(14) C]-canagliflozin, and total radio...
The use of natural language processing of infusion notes to identify outpatient infusions.
Pharmacoepidemiology and drug safety
Nov 17, 2014
PURPOSE: Outpatient infusions are commonly missing in Veterans Health Affairs (VHA) pharmacy dispensing data sets. Currently, Healthcare Common Procedure Coding System (HCPCS) codes are used to identify outpatient infusions, but concerns exist if the...
Environmental contamination, product contamination and workers exposure using a robotic system for antineoplastic drug preparation.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
Feb 23, 2014
Environmental contamination, product contamination and technicians exposure were measured following preparation of iv bags with cyclophosphamide using the robotic system CytoCare. Wipe samples were taken inside CytoCare, in the clean room environment...
Risk Assessment
Occupational Exposure
Environmental Monitoring
Infusions, Intravenous
Humans
Risk Factors
Equipment Contamination
Drug Contamination
Antineoplastic Agents, Alkylating
Pharmacy Service, Hospital
Robotics
Equipment Design
Drug Compounding
Cyclophosphamide
Air Pollutants, Occupational
Environment, Controlled
Gloves, Protective
A Software-Defined Sensor System Using Semantic Segmentation for Monitoring Remaining Intravenous Fluids.
Sensors (Basel, Switzerland)
May 13, 2025
Accurate intravenous (IV) fluid monitoring is critical in healthcare to prevent infusion errors and ensure patient safety. Traditional monitoring methods often depend on dedicated hardware, such as weight sensors or optical systems, which can be cost...
Integrating real-world data and machine learning: A framework to assess covariate importance in real-world use of alternative intravenous dosing regimens for atezolizumab.
Clinical and translational science
Nov 1, 2024
The increase in the availability of real-world data (RWD), in combination with advances in machine learning (ML) methods, provides a unique opportunity for the integration of the two to explore complex clinical pharmacology questions. Here we present...
Better Blood Pressure Control for Stroke Patients in the ICU: A Deep Reinforcement Learning with Supervised Guidance Approach for Adaptive Infusion Rate Tuning.
AMIA ... Annual Symposium proceedings. AMIA Symposium
Jan 1, 2024
Blood pressure variability (BPV) plays a critical role in vascular diseases, particularly in acute ischemic stroke patients in intensive care units (ICUs), where higher BPV correlates with increased mortality rates. Current interventions lack effecti...
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