BACKGROUND: Numerous studies have manifested that cellular senescence involves in the pathogenesis of intervertebral disc degeneration (IDD). Here, we constructed a novel senescence-related genes (SRGs) signature for IDD.
BACKGROUND: Intervertebral disc degeneration (IDD) is prevalent in orthopaedics, yet lacks effective treatments. This study seeks to discover potential therapeutic targets for IDD to inform clinical therapies and traditional medicine approaches.
Magnetic resonance imaging (MRI) serves as the clinical gold standard for diagnosing lumbar disc herniation (LDH). This multicenter study was to develop and clinically validate a deep learning (DL) model utilizing axial T2-weighted lumbar MRI sequenc...
BACKGROUND: Lumbar disc degeneration (LDD) displays considerable heterogeneity in terms of clinical features and pathological changes. However, researchers have not clearly determined whether the transcriptome variations in LDD could be used to ident...
Journal of controlled release : official journal of the Controlled Release Society
Jul 29, 2025
Intervertebral disc degeneration (IVDD) is a primary contributor to the development of low back pain, characterized by core pathological features which include extracellular matrix (ECM) degradation, oxidative stress, imbalanced inflammatory microenv...
Intervertebral disc degeneration (IDD), a prevalent spinal condition linked to low back pain, has substantial genetic components, necessitating deeper understanding of its mechanisms. This study categorized nucleus pulposus cell (NPC) populations and...
Patients with lumbar degenerative disease typically undergo preoperative MRI combined with CT scans, but this approach introduces additional ionizing radiation and examination costs. To compare the effectiveness of MRI-based synthetic CT (sCT) in dis...
Journal of orthopaedic surgery and research
May 27, 2025
Spontaneous resorption of lumbar disk herniation (LDH) presents a promising avenue for the non-surgical management of herniated disks. Here we present a 40-year-old female with severe L5/S1 herniation who experienced spontaneous resorption confirmed ...
INTRODUCTION: Aging is characterized by gradual structural and functional changes in the body over time, with intervertebral disc degeneration (IVDD) representing a key manifestation of spinal aging and a major contributor to low back pain (LBP).
The spine journal : official journal of the North American Spine Society
Apr 9, 2025
BACKGROUND CONTEXT: The paraspinal muscles play a critical role in maintaining lumbar spine stability, and different muscles may have varying impacts on lumbar disc degeneration (LDD). However, studies exploring these relationships remain relatively ...
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