Cirrhosis care is inherently complex, marked by a high risk of acute decompensation and significant morbidity and mortality. Traditional episodic care models provide static snapshots of a patient's condition, limiting the ability to address dynamic c...
BACKGROUND: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most common cause of cancer-related death. Cirrhosis is a major contributing factor, accounting for over 90% of HCC cases. With the high mortality rate...
BACKGROUND: There is uncertainty regarding the association between continuous glucose monitoring (CGM), derived glycemic metrics, and metabolic dysfunction-associated steatotic liver disease (MASLD) in individuals with type 1 diabetes (T1D).
BACKGROUND: The transjugular intrahepatic portosystemic shunt (TIPS), a crucial tool for treating complications related to portal hypertension in patients with liver cirrhosis, is often associated with an increased risk of postoperative complications...
Metabolic dysfunction-associated steatohepatitis (MASH), the progressive inflammatory form of MASLD, is now a leading cause of chronic liver disease worldwide. Driven by obesity and type 2 diabetes, MASH significantly increases the risk of cirrhosis,...
OBJECTIVES: To evaluate a deep learning sequence-adaptive liver multiparametric MRI (mpMRI) assessment with validation in different populations using total and segmental T1 and T2 relaxation time maps.
AIMS: Severe liver disease (SLD) in nonalcoholic fatty liver disease (NAFLD) is often diagnosed late due to the long asymptomatic period of progressive fibrosis. We aimed to identify metabolomic profiles associated with SLD and develop a predictive m...
Liver cirrhosis represents the end stage of chronic liver disease, characterized by extensive fibrosis and nodular regeneration that significantly increases mortality risk. While magnetic resonance imaging (MRI) offers a non-invasive assessment, accu...
Liver sinusoidal endothelial cells (LSECs) lose their characteristic fenestrations and become capillarized during the progression of liver fibrosis. Mesenchymal stem cell (MSC) transplantation can reverse this capillarization and reduce fibrosis, but...
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