RATIONALE AND OBJECTIVES: To develop and validate a multimodal deep learning (DL) model based on computed tomography (CT) images and clinical knowledge to predict lymph node metastasis (LNM) in early lung adenocarcinoma.
Patients with Non-Small Cell Lung Cancer (NSCLC) present a variety of clinical symptoms, such as dyspnea and chest pain, complicating accurate diagnosis. NSCLC includes subtypes distinguished by histological characteristics, specifically lung adenoca...
Lung cancer (LC) remains the primary cause of cancer-related mortality, largely due to late-stage diagnoses. Effective strategies for early detection are therefore of paramount importance. In recent years, machine learning (ML) has demonstrated consi...
BMC medical informatics and decision making
Dec 24, 2024
BACKGROUND: The detection and classification of lung nodules are crucial in medical imaging, as they significantly impact patient outcomes related to lung cancer diagnosis and treatment. However, existing models often suffer from mode collapse and po...
The development of phosphorylation-suppressing inhibitors targeting Signal Transducer and Activator of Transcription 3 (STAT3) represents a promising therapeutic strategy for non-small cell lung cancer (NSCLC). In this study, a generative model was d...
Cancer immunology, immunotherapy : CII
Dec 21, 2024
BACKGROUND: Existing biomarkers and models for predicting response to programmed cell death protein 1 monoclonal antibody in advanced squamous-cell non-small cell lung cancer (sqNSCLC) did not have enough accuracy. We used data from the ORIENT-3 stud...
International journal of molecular sciences
Dec 20, 2024
Liquid biopsy (LB) involves the analysis of circulating tumour-derived DNA (ctDNA), providing a minimally invasive method for gathering both quantitative and qualitative information. Genomic analysis of ctDNA through next-generation sequencing (NGS) ...
BACKGROUND: Traditional rule-based natural language processing approaches in electronic health record systems are effective but are often time-consuming and prone to errors when handling unstructured data. This is primarily due to the substantial man...
Lung cancer is a leading cause of cancer death worldwide. The survival rate is generally higher when this disease is detected in its early stages. Advances in artificial intelligence (AI) have enabled the development of decision support systems that ...
Cellular oncology (Dordrecht, Netherlands)
Dec 19, 2024
BACKGROUND: The most common type of lung cancer is non-small cell lung cancer (NSCLC), accounting for 85% of all cases. Programmed cell death (PCD), an important regulatory mechanism for cell survival and homeostasis, has become increasingly prominen...
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