With an increasing aging population, the prevalence of chronic comorbidities is on the rise. The potential relationship between obstructive sleep apnea (OSA) and osteoporosis has garnered significant attention. Most studies examining the association ...
Journal of chemical theory and computation
Sep 4, 2025
Protein function is driven by transitions between metastable conformations, many of which are not conserved across homologues, offering opportunities for selective drug design. Accurately modeling both backbone and side chain metastability, and gener...
Journal of chemical information and modeling
Sep 4, 2025
Lipids are essential metabolites that play critical roles in multiple cellular pathways. Like many primary metabolites, mutations that disrupt lipid synthesis can be lethal. Proteins involved in lipid synthesis, trafficking, and modification, are tar...
Journal of chemical information and modeling
Sep 4, 2025
Phytocystatins are proteinaceous inhibitors found in plants that competitively target various classes of cysteine proteinases, including papain-like enzymes, cathepsins, and legumains. Based on structural characteristics and gene organization, phytoc...
Terminators are specific nucleotide sequences located at the 3' end of a gene and contain transcription termination information. As a fundamental genetic regulatory element, terminators play a crucial role in the design of gene circuits. Accurately c...
Identifying the computational roles of different neuron families is crucial for understanding neural networks. Most neural diversity is embodied in various types of γ-aminobutyric acid-mediated (GABAergic) interneurons, grouped into four major famili...
Interior design is a complex and creative discipline involving aesthetics, functionality, ergonomics, and materials science. Effective solutions must meet diverse requirements, typically producing multiple deliverables such as renderings and design d...
Hospital readmissions prolong patient suffering and increase healthcare expenditures. While several studies have attempted to develop prediction models to reduce readmissions, most have demonstrated modest predictive accuracy. To improve upon prior a...
In the last decade, the free energy principle (FEP) and active inference (AIF) have achieved many successes connecting conceptual models of learning and cognition to mathematical models of perception and action. This effort is driven by a multidiscip...
BACKGROUND: Professional identity plays a critical role in the career development of male postgraduate nursing students, particularly in contexts where gender imbalance and social stereotypes persist.
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