Glycosylation changes are closely related to various diseases, including cancer. The quantitative analysis of site-specific glycans at proteomics scale remains challenging due to low glycopeptide spectra interpretation. Here, we present GlyPep-Quant,...
Innovative identification technologies for hematopoietic stem cells (HSCs) have expanded the scope of stem cell biology. Clinically, the functional quality of HSCs critically influences the safety and therapeutic efficacy of stem cell therapies. Howe...
BACKGROUND: Large language models (LLMs) have demonstrated remarkable capabilities in natural language processing tasks, including medical question-answering (QA). However, individual LLMs often exhibit varying performance across different medical QA...
OBJECTIVE: To study the association between cerebral small vessel diseases (CSVD) and unfavorable hematoma morphology in primary intracerebral hemorrhage (ICH).
Optical Diffraction Tomography (ODT) is a promising technique for three-dimensional imaging, but practical use demands rigorous robustness testing due to real-world noise factors. Despite the growing importance of machine learning safety, robustness ...
Journal of computer-aided molecular design
Jul 13, 2025
Identifying orthosteric binding sites and predicting small molecule affinities remains a key challenge in virtual screening. While blind docking explores the entire protein surface, its precision is hindered by the vast search space. Cavity detection...
Depression is a heterogeneous disorder marked by disruptions in cognitive and affective processing. While self-reported measures and clinical interviews remain the diagnostic standard, integrating objective neurophysiological markers could enhance as...
BACKGROUND: Breast cancer metastasis (BCM) metastasizes preferentially to certain organs. Important genetic markers can be used for early detection and treatment. Machine learning (ML) can efficiently handle gene expression data to enhance metastasis...
Dengue fever remains a significant global health threat, particularly in tropical and subtropical regions, where rapid urbanization and climate variability exacerbate its spread. Traditional surveillance and control systems often struggle with delaye...
An underlying association between primary open-angle glaucoma (POAG) and COVID-19 has been hypothesized, but the causal link and shared mechanisms remain unclear. This study integrates epidemiological and bioinformatics approaches to investigate thei...
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