Given that influenza vaccine effectiveness depends on a good antigenic match between the vaccine and circulating viruses, it is important to assess the antigenic properties of newly emerging variants continuously. With the increasing application of r...
Drug-drug interactions (DDIs) present serious risks in clinical settings, especially for patients who are prescribed multiple medications. A major factor contributing to these interactions is the inhibition of cytochrome P450 (CYP450) enzymes, which ...
Cancer-associated fibroblasts (CAFs) play important roles in the progression of lung adenocarcinoma (LUAD). We examined CAF subgroups via gene ontology, pseudo-time, and cell communication analyses and explored their prognostic value in LUAD using a ...
We use machine learning to identify innovative strategies to target azithromycin to the children with watery diarrhea who are most likely to benefit. Using data from a randomized trial of azithromycin for watery diarrhea (NCT03130114), we develop per...
Clinical notes should capture important information from a physician-patient encounter, but they may also contain signals indicative of physician fatigue. Using data from 129,228 emergency department (ED) visits, we train a model to identify notes wr...
Reactive oxygen species (ROS) are highly reactive molecules encountered by yeasts during routine metabolism and during interactions with other organisms, including host infection. Here, we characterize the variation in resistance to the ROS-inducing ...
PURPOSE: Pancreatic cancer (PC) is one of the most lethal malignancies, often presenting with nonspecific symptoms and a dismal prognosis. Despite advancements in treatments, the 5-year survival rate remains low, highlighting the urgent need for effe...
Artificial intelligence (AI) has been applied to early recognition and management of rapidly progressive, community-acquired pediatric sepsis, a leading cause of childhood mortality. The broad adoption of electronic health records combined with rapid...
AIMS: BoneFinder is a machine-learning tool that can automatically calculate Reimers migration percentage (RMP) and head-shaft angle (HSA) from paediatric cerebral palsy (CP) pelvic radiographs. This study's primary aim was to compare BoneFinder's fu...
BACKGROUND: The integration of machine learning and deep learning methodologies has transformed data analytics in biomechanics. However, the field faces challenges such as limited large-scale data sets, high data acquisition costs, and restricted par...
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