BACKGROUND: Hashimoto's thyroiditis (HT) is a common benign thyroid disease that often coexists with papillary thyroid carcinoma (PTC). Owing to the diffuse changes in the thyroid caused by HT, PTCs can be challenging to detect using conventional ima...
BACKGROUND: Genomic Best Linear Unbiased Prediction (GBLUP) assumes that all SNPs contribute equally to genetic variance, including those with minimal impact, limiting its accuracy. A major challenge in animal breeding is to develop more scientific m...
Esophageal carcinoma poses a significant health challenge, particularly due to its notably high prevalence in East Asia, which underscores the urgent need for innovative treatment strategies. Natural flavonoids are polyphenolic compounds with signifi...
A high-accuracy DNA-based cancer risk predictor was developed by blending Logistic Regression with Gaussian Naive Bayes, and its hyperparameters were optimized via grid search. Five cancer types (BRCA1, KIRC, COAD, LUAD, PRAD) were classified in a co...
Physical chemistry chemical physics : PCCP
Nov 12, 2025
Fluoroquinolones (FQs) are a family of antibiotic drugs well-known for their high photochemical activity: upon UV-vis excitation FQs may produce singlet oxygen and/or lose the fluorine atom. Pterins (Ptrs) are a class of organic photosensitizers with...
Asthma is a chronic respiratory disease characterized by wheezing and difficulty breathing, which disproportionally affects 4.7 million children in the U.S. Currently, there is a lack of asthma predictive models for youth with good performance. This ...
OBJECTIVE: With the global increase in obesity rates and lifestyle changes, metabolic dysfunction-associated steatotic liver disease (MASLD) has become a prevalent chronic liver disorder, affecting approximately 25% of the global population. This dis...
Per- and polyfluoroalkyl substances (PFAS) are over 14 000 synthetic compounds with exceptional environmental persistence. Used extensively in industrial and consumer applications, PFAS resist degradation and accumulate in environmental media and liv...
Journal of chemical information and modeling
Nov 11, 2025
Molecular dynamics (MD) simulations are currently widely used to study large-scale displacement cascades based on massive simulation trajectories. However, when the irradiation process involves the complex chemical reactions, effectively analyzing an...
Journal of the American Heart Association
Nov 11, 2025
BACKGROUND: Despite the established link between metabolic syndrome (MetS) and stroke incidence, the effects of dynamic and cumulative MetS scores on stroke risk among middle-aged and older populations in China remain inadequately explored. Furthermo...
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