Journal of the American Chemical Society
Oct 22, 2025
Fragment-Based Drug Discovery (FBDD) is a powerful strategy used in the development of new therapeutics. Molecular fragments are screened against a target protein, where interactions are typically characterized by a low affinity. Nuclear Magnetic Res...
Very persistent and very mobile (vPvM) substances threaten the environment and human health. These chemicals can persist in aquatic systems and move rapidly due to their affinity for water over soil or other adsorbents. Chemical mobility is usually c...
BACKGROUND: Type 2 diabetes (T2D) and its vascular complications, including diabetic retinopathy (DR), are escalating in prevalence globally, with disproportionately high prevalence in Middle Eastern populations, where genetic predispositions and lif...
BACKGROUND: Serum lipase levels are crucial biomarkers in acute pancreatitis (AP), yet their dynamic patterns and prognostic implications remain incompletely understood. This study aimed to identify distinct lipase trajectory phenotypes and evaluate ...
OBJECTIVE: This study investigated the relationship between estimated glucose disposal rate (eGDR), aging acceleration (AgeAccel), and mortality in adults diagnosed with cardiovascular-kidney-metabolic (CKM) stages 1 to 4.
Journal of neuroengineering and rehabilitation
Oct 22, 2025
BACKGROUND: This study utilized artificial intelligence (AI)-based machine learning algorithms, alongside the shapley additive explanations (SHAP) framework, to identify lower-limb muscle force patterns associated with recurrent patellofemoral pain (...
BMC medical informatics and decision making
Oct 22, 2025
BACKGROUND: Carbapenemase-Producing Enterobacteriace (CPE) poses a critical concern for infection prevention and control in hospitals. However, predictive modeling of previously highlighted CPE-associated risks such as readmission, mortality, and ext...
Children with disabilities frequently encounter considerable obstacles in acquiring self-care skills, which are vigorous for developing their independence and overall quality of life. The early detection of self-care deficits is important for prompt ...
Endemic and endangered bird species, such as Salvadori serin (C. xantholaema), are vulnerable to environmental and anthropogenic changes. Understanding the impact of climate change on ecological niches is essential for effective conservation. This st...
Visual aesthetic preferences fundamentally shape the restorative potential of university landscapes and have a significant impact on student well-being and engagement. This study developed Ensemble Learning Models to predict students' aesthetic prefe...
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