AI Medical Compendium Topic

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Mechanotransduction, Cellular

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Texture recognition and localization in amorphous robotic skin.

Bioinspiration & biomimetics
We present a soft robotic skin that can recognize and localize texture using a distributed set of sensors and computational elements that are inspired by the Pacinian corpuscle, the fast adapting, uniformly spaced mechanoreceptor with a wide receptiv...

Machine learning based methodology to identify cell shape phenotypes associated with microenvironmental cues.

Biomaterials
Cell morphology has been identified as a potential indicator of stem cell response to biomaterials. However, determination of cell shape phenotype in biomaterials is complicated by heterogeneous cell populations, microenvironment heterogeneity, and m...

Non-equilibrium-Growing Aesthetic Ionic Skin for Fingertip-Like Strain-Undisturbed Tactile Sensation and Texture Recognition.

Advanced materials (Deerfield Beach, Fla.)
Humans use periodically ridged fingertips to precisely perceive the characteristics of objects via ion-based fast- and slow-adaptive mechanotransduction. However, designing artificial ionic skins with fingertip-like tactile capabilities remains chall...

A machine learning approach to predict cellular mechanical stresses in response to chemical perturbation.

Biophysical journal
Mechanical stresses generated at the cell-cell level and cell-substrate level have been suggested to be important in a host of physiological and pathological processes. However, the influence various chemical compounds have on the mechanical stresses...

Regulated Behavior in Living Cells with Highly Aligned Configurations on Nanowrinkled Graphene Oxide Substrates: Deep Learning Based on Interplay of Cellular Contact Guidance.

ACS nano
Micro-/nanotopographical cues have emerged as a practical and promising strategy for controlling cell fate and reprogramming, which play a key role as biophysical regulators in diverse cellular processes and behaviors. Extracellular biophysical facto...

Robotic Actuation-Mediated Quantitative Mechanogenetics for Noninvasive and On-Demand Cancer Therapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cell mechanotransduction signals are important targets for physical therapy. However, current physiotherapy heavily relies on ultrasound, which is generated by high-power equipment or amplified by auxiliary drugs, potentially causing undesired side e...

Invited Review for 20th Anniversary Special Issue of PLRev "AI for Mechanomedicine".

Physics of life reviews
Mechanomedicine is an interdisciplinary field that combines different areas including biomechanics, mechanobiology, and clinical applications like mechanodiagnosis and mechanotherapy. The emergence of artificial intelligence (AI) has revolutionized m...