AIMC Topic: Metabolic Clearance Rate

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Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients.

International journal of antimicrobial agents Dec 22, 2017
Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models constructed with intermittent infusion data. However, the probability of targ...
Piperacillin Pseudomonas Infections Infusions, Intravenous Creatinine Pseudomonas aeruginosa Tazobactam Metabolic Clearance Rate Penicillanic Acid Microbial Sensitivity Tests Kidney Function Tests Drug Combinations Middle Aged Sepsis Critical Illness Female Male Humans Anti-Bacterial Agents
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Pharmacokinetics of single and repeat doses of icatibant.

Clinical pharmacology in drug development Feb 2, 2015
PURPOSE: Icatibant is a bradykinin-2 receptor antagonist approved to treat acute hereditary angioedema attacks in adults. To-date, no thorough investigation of the clinical pharmacokinetic (PK) parameters of icatibant and its primary metabolites has ...
Humans Anti-Inflammatory Agents, Non-Steroidal Healthy Volunteers Metabolic Clearance Rate Area Under Curve Female Half-Life Bradykinin Models, Biological Adult Young Adult Bradykinin B2 Receptor Antagonists Drug Administration Schedule Adolescent Male Injections, Subcutaneous Middle Aged
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THE EFFECT OF TOTAL AND PARTIAL NEPHRECTOMY ON THE PHARMACOKINETICS OF INTRAVENOUS PARACETAMOL IN HUMANS.

Acta poloniae pharmaceutica May 1, 2017
Paracetamol is one of the most common analgesic and antipyretic drugs. Recently intravenous paracetamol has been widely used to treat moderate postoperative pain. Surgery is the main method of treatment of renal cancer. Total or partial nephrectomy c...
Models, Biological Antipyretics Chromatography, High Pressure Liquid Biological Availability Half-Life Kidney Neoplasms Infusions, Intravenous Area Under Curve Renal Elimination Drug Monitoring Aged, 80 and over Middle Aged Adult Humans Kidney Metabolic Clearance Rate Acetaminophen Male Female Spectrophotometry, Ultraviolet Analgesics, Non-Narcotic Aged Nephrectomy
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PHARMACOKINETICS AND BIOEQUIVALENCE STUDIES OF TWO NIMESULIDE 100 mg TABLETS: UNIT DOSE, RANDOMIZED-SEQUENCE, TWO-WAY CROSSOVER STUDY IN HEALTHY VOLUNTEERS OF PAKISTANI POPULATION.

Acta poloniae pharmaceutica Mar 1, 2017
Single centered crossover, two cycles volunteer study was performed on 12 healthy male volunteers. Both reference and test, immediate release nimesulide formulation was given in a randomized manner with a washout period of 15 days and 5 mL of blood s...
Half-Life Models, Biological Cross-Over Studies Chromatography, High Pressure Liquid Metabolic Clearance Rate Sulfonamides Male Healthy Volunteers Therapeutic Equivalency Pakistan Tablets Anti-Inflammatory Agents, Non-Steroidal Humans Administration, Oral Area Under Curve Young Adult
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Pharmacodynamics and Pharmacokinetics of Levobupivacaine Used for Epidural Anesthesia in Patients with Liver Dysfunction.

Cell biochemistry and biophysics Dec 1, 2015
The objective of this study was to study the pharmacodynamics and pharmacokinetics of levobupivacaine used for epidural anesthesia in patients with liver dysfunction. Twenty patients aged 20-60, American Society of Anesthesiologists (ASA) graded I-II...
Humans Female Adult Bupivacaine Sensation Spinal Nerves Male Middle Aged Anesthetics, Local Metabolic Clearance Rate Tissue Distribution Levobupivacaine Liver Diseases Anesthesia, Epidural
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