AIMC Topic: Mice, Inbred C57BL

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Structure-aware machine learning identifies microRNAs operating as Toll-like receptor 7/8 ligands.

RNA biology Jul 9, 2021
MicroRNAs (miRNAs) can serve as activation signals for membrane receptors, a recently discovered function that is independent of the miRNAs' conventional role in post-transcriptional gene regulation. Here, we introduce a machine learning approach, Br...
Humans Machine Learning Animals Oligonucleotides Toll-Like Receptor 7 Ligands Gene Expression Regulation Toll-Like Receptor 8 Mice Mice, Inbred C57BL MicroRNAs Microglia
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Automated Detection and Diameter Estimation for Mouse Mesenteric Artery Using Semantic Segmentation.

Journal of vascular research Jun 28, 2021
BACKGROUND: Pressurized myography is useful for the assessment of small artery structures and function. However, this procedure requires technical expertise for sample preparation and effort to choose an appropriate sized artery. In this study, we de...
Mice, Inbred C57BL Mesenteric Veins Animals Predictive Value of Tests Mice, Transgenic Male Automation Microscopy Myography Mice Arterial Pressure Image Interpretation, Computer-Assisted Mesenteric Arteries Genotype Neural Networks, Computer Machine Learning Phenotype Female
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Multi-View Mouse Social Behaviour Recognition With Deep Graphic Model.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society Jun 11, 2021
Home-cage social behaviour analysis of mice is an invaluable tool to assess therapeutic efficacy of neurodegenerative diseases. Despite tremendous efforts made within the research community, single-camera video recordings are mainly used for such ana...
Deep Learning Image Processing, Computer-Assisted Mice Mice, Inbred C57BL Video Recording Humans Parkinsonian Disorders Female Behavior, Animal Animals Social Behavior
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Low-dimensional learned feature spaces quantify individual and group differences in vocal repertoires.

eLife May 14, 2021
Increases in the scale and complexity of behavioral data pose an increasing challenge for data analysis. A common strategy involves replacing entire behaviors with small numbers of handpicked, domain-specific features, but this approach suffers from ...
Behavior, Animal Songbirds Vocalization, Animal Mice, Inbred DBA Mice Mice, Inbred C57BL Signal Processing, Computer-Assisted Ultrasonics Learning Animals Male Machine Learning Data Analysis
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Overcoming false-positive gene-category enrichment in the analysis of spatially resolved transcriptomic brain atlas data.

Nature communications May 11, 2021
Transcriptomic atlases have improved our understanding of the correlations between gene-expression patterns and spatially varying properties of brain structure and function. Gene-category enrichment analysis (GCEA) is a common method to identify func...
Humans Male Gene Expression Profiling Mice Mice, Inbred C57BL Molecular Sequence Annotation Software Brain Reproducibility of Results Animals Gene Ontology
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Pseudocell Tracer-A method for inferring dynamic trajectories using scRNAseq and its application to B cells undergoing immunoglobulin class switch recombination.

PLoS computational biology May 3, 2021
Single cell RNA sequencing (scRNAseq) can be used to infer a temporal ordering of cellular states. Current methods for the inference of cellular trajectories rely on unbiased dimensionality reduction techniques. However, such biologically agnostic or...
NF-kappa B p50 Subunit STAT6 Transcription Factor Receptors, Cytokine Recombination, Genetic Basic-Leucine Zipper Transcription Factors Immunoglobulin Class Switching Mice Computational Biology Signal Transduction Computer Simulation Mice, Inbred C57BL Animals Supervised Machine Learning Single-Cell Analysis Neural Networks, Computer Gene Expression RNA-Seq Databases, Nucleic Acid B-Lymphocytes Interleukin-4 Models, Immunological Immunoglobulin G
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Neurovascular multiparametric MRI defines epileptogenic and seizure propagation regions in experimental mesiotemporal lobe epilepsy.

Epilepsia Apr 5, 2021
OBJECTIVE: Improving the identification of the epileptogenic zone and associated seizure-spreading regions represents a significant challenge. Innovative brain-imaging modalities tracking neurovascular dynamics during seizures may provide new disease...
Brain Mapping Hippocampus Epilepsy, Temporal Lobe Image Processing, Computer-Assisted Multiparametric Magnetic Resonance Imaging Mice Disease Models, Animal Mice, Inbred C57BL Machine Learning Animals Male
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Action detection using a neural network elucidates the genetics of mouse grooming behavior.

eLife Mar 17, 2021
Automated detection of complex animal behaviors remains a challenging problem in neuroscience, particularly for behaviors that consist of disparate sequential motions. Grooming is a prototypical stereotyped behavior that is often used as an endopheno...
Ethology Neural Networks, Computer Machine Learning Female Animals Mice, Inbred C57BL Behavior, Animal Male Grooming Mice
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Single Cell RNA-Seq and Machine Learning Reveal Novel Subpopulations in Low-Grade Inflammatory Monocytes With Unique Regulatory Circuits.

Frontiers in immunology Feb 23, 2021
Subclinical doses of LPS (SD-LPS) are known to cause low-grade inflammatory activation of monocytes, which could lead to inflammatory diseases including atherosclerosis and metabolic syndrome. Sodium 4-phenylbutyrate is a potential therapeutic compou...
Mice, Inbred C57BL Quality Control Phenylbutyrates Gene Regulatory Networks Mice Monocytes Lipopolysaccharides Machine Learning Animals Male Single-Cell Analysis RNA-Seq
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Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning.

PLoS computational biology Feb 22, 2021
Phenotypic profiling of large three-dimensional microscopy data sets has not been widely adopted due to the challenges posed by cell segmentation and feature selection. The computational demands of automated processing further limit analysis of hard-...
Machine Learning Software Algorithms Phenotype Imaging, Three-Dimensional Image Processing, Computer-Assisted Mice Brain Animals Microscopy, Fluorescence Humans Neurons Apoptosis Programming Languages Mice, Inbred C57BL Mammary Glands, Human Cell Line Organoids Autophagy
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