AIMC Topic: Mice
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Hybrid-Actuating Macrophage-Based Microrobots for Active Cancer Therapy.
Scientific reports
Jun 27, 2016
Using macrophage recruitment in tumors, we develop active, transportable, cancer theragnostic macrophage-based microrobots as vector to deliver therapeutic agents to tumor regions. The macrophage-based microrobots contain docetaxel (DTX)-loaded poly-...
NegGOA: negative GO annotations selection using ontology structure.
Bioinformatics (Oxford, England)
Jun 17, 2016
MOTIVATION: Predicting the biological functions of proteins is one of the key challenges in the post-genomic era. Computational models have demonstrated the utility of applying machine learning methods to predict protein function. Most prediction met...
GGIP: Structure and sequence-based GPCR-GPCR interaction pair predictor.
Proteins
Jun 8, 2016
G Protein-Coupled Receptors (GPCRs) are important pharmaceutical targets. More than 30% of currently marketed pharmaceutical medicines target GPCRs. Numerous studies have reported that GPCRs function not only as monomers but also as homo- or hetero-d...
Integrated Analysis of Expression Profile Based on Differentially Expressed Genes in Middle Cerebral Artery Occlusion Animal Models.
International journal of molecular sciences
May 20, 2016
Stroke is one of the most common causes of death, only second to heart disease. Molecular investigations about stroke are in acute shortage nowadays. This study is intended to explore a gene expression profile after brain ischemia reperfusion. Meta-a...
Clustering Single-Cell Expression Data Using Random Forest Graphs.
IEEE journal of biomedical and health informatics
May 10, 2016
Complex tissues such as brain and bone marrow are made up of multiple cell types. As the study of biological tissue structure progresses, the role of cell-type-specific research becomes increasingly important. Novel sequencing technology such as sing...
Learning of speckle statistics for in vivo and noninvasive characterization of cutaneous wound regions using laser speckle contrast imaging.
Microvascular research
Apr 27, 2016
Laser speckle contrast imaging (LSCI) provides a noninvasive and cost effective solution for in vivo monitoring of blood flow. So far, most of the researches consider changes in speckle pattern (i.e. correlation time of speckle intensity fluctuation)...
Sarcoma 180
Mice
Blood Flow Velocity
Wound Healing
Laser-Doppler Flowmetry
Disease Models, Animal
Microcirculation
Predictive Value of Tests
Area Under Curve
Regional Blood Flow
Animals
Perfusion Imaging
Data Interpretation, Statistical
Reproducibility of Results
Image Interpretation, Computer-Assisted
Skin
Male
Immunohistochemistry
Supervised Machine Learning
Time Factors
ROC Curve
Investigation of the mutagenic and genotoxic activities of LLL-3, a STAT3 inhibitor.
Drug and chemical toxicology
Apr 10, 2016
LLL-3, an anthracene derived compound, has been shown to be a promising therapeutic agent for the treatment of some kinds of cancer such as chronic myeloid leukemia and glioblastoma. However, no data regarding the toxic properties of this compound ha...
RegenBase: a knowledge base of spinal cord injury biology for translational research.
Database : the journal of biological databases and curation
Apr 7, 2016
Spinal cord injury (SCI) research is a data-rich field that aims to identify the biological mechanisms resulting in loss of function and mobility after SCI, as well as develop therapies that promote recovery after injury. SCI experimental methods, da...
Development of a Microforce Sensor and Its Array Platform for Robotic Cell Microinjection Force Measurement.
Sensors (Basel, Switzerland)
Apr 6, 2016
Robot-assisted cell microinjection, which is precise and can enable a high throughput, is attracting interest from researchers. Conventional probe-type cell microforce sensors have some real-time injection force measurement limitations, which prevent...
The Disease Portals, disease-gene annotation and the RGD disease ontology at the Rat Genome Database.
Database : the journal of biological databases and curation
Mar 23, 2016
The Rat Genome Database (RGD;http://rgd.mcw.edu/) provides critical datasets and software tools to a diverse community of rat and non-rat researchers worldwide. To meet the needs of the many users whose research is disease oriented, RGD has created a...
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