AIMC Topic: MicroRNAs

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GONNMDA: A Ordered Message Passing GNN Approach for miRNA-Disease Association Prediction.

Genes
Small non-coding molecules known as microRNAs (miRNAs) play a critical role in disease diagnosis, treatment, and prognosis evaluation. Traditional wet-lab methods for validating miRNA-disease associations are often time-consuming and inefficient. Wit...

Multitask learning model for predicting non-coding RNA-disease associations: Incorporating local and global context.

Methods (San Diego, Calif.)
Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are crucial non-coding RNAs involved in various diseases. Understanding these interactions is vital for advancing diagnostic, preventive, and therapeutic strategies. Existing computational methods...

miRNA-Based Diagnosis of Schizophrenia Using Machine Learning.

International journal of molecular sciences
Diagnostic practices for schizophrenia are unreliable due to the lack of a stable biomarker. However, machine learning holds promise in aiding in the diagnosis of schizophrenia and other neurological disorders. Dysregulated miRNAs were extracted from...

Identification of novel diagnostic and prognostic microRNAs in sarcoma on TCGA dataset: bioinformatics and machine learning approach.

Scientific reports
The discovery of unique microRNA (miR) patterns and their corresponding genes in sarcoma patients indicates their involvement in cancer development and suggests their potential use in medical management. MiRs were identified from The Cancer Genome At...

Machine Learning-Aided Identification of Fecal Extracellular Vesicle microRNA Signatures for Noninvasive Detection of Colorectal Cancer.

ACS nano
Colorectal cancer (CRC) remains a formidable threat to human health, with considerable challenges persisting in its diagnosis, particularly during the early stages of the malignancy. In this study, we elucidated that fecal extracellular vesicle micro...

Machine Learning-Aided Intelligent Monitoring of Multivariate miRNA Biomarkers Using Bipolar Self-powered Sensors.

ACS nano
Breast cancer has become the most prevalent form of cancer among women on a global scale. The early and timely diagnosis of breast cancer is of the utmost importance for improving the survival rate of patients with this disease. The occurrence of bre...

Identification of Biomarkers for Response to Interferon in Chronic Hepatitis B Based on Bioinformatics Analysis and Machine Learning.

Viral immunology
Interferon (IFN) is a pivotal agent against hepatitis B virus (HBV) in clinic, but there is a lack of accurate biomarkers to predict the response to IFN therapy in patients with chronic hepatitis B (CHB). Our study aimed to investigate potential targ...

Classification patterns identification of immunogenic cell death-related genes in heart failure based on deep learning.

Scientific reports
Heart failure (HF) is a complex and prevalent condition, particularly in the elderly, presenting symptoms like chest tightness, shortness of breath, and dyspnea. The study aimed to improve the classification of HF subtypes and identify potential drug...

Identification of biomarkers associated with phagocytosis regulatory factors in coronary artery disease using machine learning and network analysis.

Mammalian genome : official journal of the International Mammalian Genome Society
BACKGROUND: Coronary artery disease (CAD) is the leading cause of death worldwide, and aberrant phagocytosis may be involved in its development. Understanding this aspect may provide new avenues for prompt CAD diagnosis.

Deep learning-based clustering for endotyping and post-arthroplasty response classification using knee osteoarthritis multiomic data.

Annals of the rheumatic diseases
OBJECTIVES: Primary knee osteoarthritis (KOA) is a heterogeneous disease with clinical and molecular contributors. Biofluids contain microRNAs and metabolites that can be measured by omic technologies. Multimodal deep learning is adept at uncovering ...