AIMC Topic: Microsatellite Instability
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Machine learning-based prediction of microsatellite instability and high tumor mutation burden from contrast-enhanced computed tomography in endometrial cancers.
Scientific reports
Oct 20, 2020
To evaluate whether radiomic features from contrast-enhanced computed tomography (CE-CT) can identify DNA mismatch repair deficient (MMR-D) and/or tumor mutational burden-high (TMB-H) endometrial cancers (ECs). Patients who underwent targeted massive...
Carcinoma, Endometrioid
DNA Polymerase II
Poly-ADP-Ribose Binding Proteins
Mutation
Tumor Suppressor Protein p53
Endometrial Neoplasms
Computer Simulation
Aged
Prognosis
Middle Aged
Tomography, X-Ray Computed
Cohort Studies
Female
Uterus
Humans
Neoplasm Staging
Machine Learning
Microsatellite Instability
DNA Mismatch Repair
Colorectal Cancer: Microsatellite Instability/Mismatch Repair Testing in the Era of Digital Pathology.
Gastroenterology
Aug 13, 2020
A deep learning model to predict RNA-Seq expression of tumours from whole slide images.
Nature communications
Aug 3, 2020
Deep learning methods for digital pathology analysis are an effective way to address multiple clinical questions, from diagnosis to prediction of treatment outcomes. These methods have also been used to predict gene mutations from pathology images, b...
Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning.
Gastroenterology
Jun 17, 2020
BACKGROUND & AIMS: Microsatellite instability (MSI) and mismatch-repair deficiency (dMMR) in colorectal tumors are used to select treatment for patients. Deep learning can detect MSI and dMMR in tumor samples on routine histology slides faster and le...
Multifactorial Deep Learning Reveals Pan-Cancer Genomic Tumor Clusters with Distinct Immunogenomic Landscape and Response to Immunotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Jan 7, 2020
PURPOSE: Tumor genomic features have been of particular interest because of their potential impact on the tumor immune microenvironment and response to immunotherapy. Due to the substantial heterogeneity, an integrative approach incorporating diverse...
A gastric cancer LncRNAs model for MSI and survival prediction based on support vector machine.
BMC genomics
Nov 13, 2019
BACKGROUND: Recent studies have shown that long non-coding RNAs (lncRNAs) play a crucial role in the induction of cancer through epigenetic regulation, transcriptional regulation, post-transcriptional regulation and other aspects, thus participating ...
Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer.
Nature medicine
Jun 3, 2019
Microsatellite instability determines whether patients with gastrointestinal cancer respond exceptionally well to immunotherapy. However, in clinical practice, not every patient is tested for MSI, because this requires additional genetic or immunohis...
Computed Tomography-Based Radiomic Features Could Potentially Predict Microsatellite Instability Status in Stage II Colorectal Cancer: A Preliminary Study.
Academic radiology
Mar 28, 2019
RATIONALE AND OBJECTIVES: To investigate whether quantitative radiomics features extracted from computed tomography (CT) can predict microsatellite instability (MSI) status in an Asian cohort of patients with stage Ⅱ colorectal cancer (CRC).
MSIpred: a python package for tumor microsatellite instability classification from tumor mutation annotation data using a support vector machine.
Scientific reports
Dec 3, 2018
Microsatellite instability (MSI) is characterized by high degree of polymorphism in microsatellite lengths due to deficiency in mismatch repair (MMR) system. MSI is associated with several tumor types and its status can be considered as an important ...
[Progress in neoadjuvant immunotherapy for locally advanced rectal cancer].
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
Jun 25, 2025
Neoadjuvant chemoradiotherapy (NACRT) is the standard treatment for locally advanced rectal cancer (LARC), yet the pathological complete response (pCR) rates remain suboptimal. The introduction of immunotherapy has opened new avenues for LARC managem...
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