AIMC Topic: Middle Aged
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Mitochondrial haplogroup A2 is associated with increased COVID-19 mortality in an admixed Brazilian population.
Scientific reports
Jul 1, 2025
Mitochondria play a crucial role in cellular respiration and immune responses. Mitochondrial DNA (mtDNA) haplogroups and variants have been associated with various diseases, including COVID-19. This study analyzed complete mtDNA sequences from 467 Br...
Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.
Nature communications
Jul 1, 2025
Extracellular vesicles (EVs) in plasma are composed of exosomes, microvesicles, and apoptotic bodies. We report a plasma EV enrichment strategy using magnetic beads called Mag-Net. Proteomic interrogation of this plasma EV fraction enables the detect...
Predicting car accident severity in Northwest Ethiopia: a machine learning approach leveraging driver, environmental, and road conditions.
Scientific reports
Jul 1, 2025
Road traffic accidents (RTAs) in Northwest Ethiopia, a region with a fatality rate of 32.2 per 100,000 residents, pose a critical public health challenge exacerbated by infrastructural deficits and environmental hazards. This study leverages machine ...
Single pulse electrical stimulation of the medial thalamic surface induces narrower high gamma band activities in the sensorimotor cortex.
Scientific reports
Jul 1, 2025
The human thalamus projects nerve fibers to all cortical regions and propagates epileptic activity. However, opportunities to directly record thalamic and cortical neural activities simultaneously are extremely limited and their electrophysiological ...
Auto-Segmentation via deep-learning approaches for the assessment of flap volume after reconstructive surgery or radiotherapy in head and neck cancer.
Scientific reports
Jul 1, 2025
Reconstructive flap surgery aims to restore the substance and function losses associated with tumor resection. Automatic flap segmentation could allow quantification of flap volume and correlations with functional outcomes after surgery or post-opera...
Predicting diabetic peripheral neuropathy through advanced plantar pressure analysis: a machine learning approach.
Scientific reports
Jul 1, 2025
Diabetic foot Ulceration (DFU) is a severe complication of diabetic foot syndrome, often leading to amputation. In patients with neuropathy, ulcer formation is facilitated by elevated plantar tissue stress under insensate feet. This study presents a ...
Integrated artificial intelligence in healthcare and the patient's experience of care.
Scientific reports
Jul 1, 2025
Healthcare is plagued with many problems that Artificial Intelligence (AI) can ameliorate or sometimes amplify. Regardless, AI is changing the way we reason towards solutions, especially at the frontier of public health applications where autonomous ...
Preoperative prediction of major adverse outcomes after total arch replacement in acute type A aortic dissection based on machine learning ensemble.
Scientific reports
Jul 1, 2025
A machine learning model was developed and validated to predict postoperative complications in patients with acute type A aortic dissection (ATAAD) who underwent total arch replacement combined with frozen elephant trunk (TAR + FET), with the goal of...
Shared gene signatures and molecular mechanisms link ankylosing spondylitis and rheumatoid arthritis.
Scientific reports
Jul 1, 2025
Ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are closely related autoimmune diseases with shared mechanisms that remain unclear. This study aims to identify shared molecular signatures and hub genes underlying the co-occurrence of AS and...
Integrated analysis of shared gene expression signatures and immune microenvironment heterogeneity in type 2 diabetes mellitus and colorectal cancer.
Scientific reports
Jul 1, 2025
Emerging evidence suggests a bidirectional relationship between colorectal cancer (CRC) and type 2 diabetes mellitus (T2DM), yet the shared molecular mechanisms and prognostic biomarkers remain poorly characterized. This study aimed to identify novel...
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