AIMC Topic: Middle Aged

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Machine learning analysis of coagulation-related genes for breast cancer diagnosis and prognosis prediction.

Scientific reports
The purpose of this study was to investigate the relationship between coagulation related genes (CRGs) and breast cancer (BC). First, we found that most CRGs are abnormally expressed in BC patients and correlated with their prognosis. Therefore, we e...

Optimising hyperparameters with a tree structured Parzen estimator to improve diabetes prediction.

Scientific reports
Diabetes is a lifelong condition that occurs when the pancreas loses its ability to secrete insulin or experiences a significant reduction in insulin production. Early identification of high-risk patients is crucial for timely interventions and impro...

Novel electroencephalographic biomarkers for the prediction of responders to an experimental glutamatergic agent in patients with schizophrenia.

Translational psychiatry
All medications currently used to treat schizophrenia, which exert their therapeutic effects by inhibiting dopaminergic neurotransmission, have their greatest efficacy against the positive symptoms of schizophrenia but have limited impact on negative...

Effect of mahjong, a Chinese tiled-based game, combined with upper limb robot training on upper limb function and rehabilitation participation in Chinese stroke patients: a clinical trial protocol.

BMJ open
INTRODUCTION: Stroke is the second leading cause of death and disability creating a huge economic burden annually. Robot-assisted training (RT) is a promising therapy in stroke rehabilitation, but for the elderly, traditional 'reaching objects'" task...

Development and validation of a model for predicting depression risk in primary palmar hyperhidrosis: a cross-sectional retrospective observational study.

BMJ open
OBJECTIVE: Primary palmar hyperhidrosis (PPH), characterised by excessive palm sweating, significantly impacts patients' physiology, psychology, self-esteem, work, life and social interactions. The incidence of depression is higher among PPH patients...

ChatGPT-Based Chatbot for Help Quitting Smoking via Text Messaging: An Interventional Study.

JMIR formative research
BACKGROUND: Large language model chatbots such as ChatGPT may be able to provide support to people who smoke cigarettes and are trying to quit.

Evaluation of Machine Learning Model Performance in Diabetic Foot Ulcer: Retrospective Cohort Study.

JMIR medical informatics
BACKGROUND: Machine learning (ML) has shown great potential in recognizing complex disease patterns and supporting clinical decision-making. Diabetic foot ulcers (DFUs) represent a significant multifactorial medical problem with high incidence and se...

Optimizing Loop Diuretic Treatment for Mortality Reduction in Patients With Acute Dyspnea Using a Practical Offline Reinforcement Learning Pipeline for Health Care: Retrospective Single-Center Simulation Study.

JMIR medical informatics
BACKGROUND: Offline reinforcement learning (RL) has been increasingly applied to clinical decision-making problems. However, due to the lack of a standardized pipeline, prior work often relied on strategies that may lead to overfitted policies and in...

Iloprost therapy achieves good clinical and radiological short and mid-term outcomes in patients with idiopathic aseptic osteonecrosis of the knee joint also in ARCO level II.

Archives of orthopaedic and trauma surgery
AIMS: The aim of this retrospective study was the evaluation of the patient-reported and radiological outcome of intravenous Iloprost therapy in the treatment of spontaneous osteonecrosis of the knee (SONK).