Journal of the Royal Society, Interface
Jun 1, 2025
Large language models (LLMs) have transformed artificial intelligence (AI) and achieved breakthrough performance on a wide range of tasks. In science, the most interesting application of LLMs is for hypothesis formation. A feature of LLMs, which resu...
Journal of biochemical and molecular toxicology
Jun 1, 2025
Experimental model systems, especially animal models, are indispensable tools to study human diseases and to develop new therapeutics. Chronic kidney disease (CKD) is a major global health problem having significantly higher rate of morbidity and mor...
The blood-brain barrier (BBB) functions as a vital protective mechanism, restricting the entry of substances and xenobiotics into the central nervous system (CNS). Consequently, BBB penetration is a critical aspect of absorption, distribution, metabo...
CPT: pharmacometrics & systems pharmacology
Jun 1, 2025
Selective serotonin reuptake inhibitors (SSRIs) are widely used in depression treatment. However, the relationship between treatment efficacy and plasma concentrations remains unclear. We assessed whether the anti-depressive response can be predicted...
BACKGROUND: Cholera outbreaks pose significant health concerns, particularly through freshwater contamination through zooplankton serving as reservoirs for Vibrio Cholerae. Understanding these complex interactions within the aquatic ecosystem through...
The design of continuum robots often involves a dilemma between flexibility and stiffness, where increased flexibility may reduce stiffness and control precision. The human hand achieves both power grasp and precision grasp by leveraging different jo...
International journal of pharmaceutics
May 15, 2025
Quantitative structure-activity relationship (QSAR) methods have emerged as powerful tools to streamline non-clinical pharmacokinetic (PK) studies, with extensive evidence demonstrating their potential to predict key in vivo PK parameters such as cle...
Spores of bacteria are metabolically dormant, resistant to microbicides, and vectors of food spoilage and diseases and survive for years in their dormant state. Upon exposure to nutrient germinants, spores can rapidly return to life through germinati...
Since every flight ends in a landing and every landing is a potential crash, deceleration during landing is one of the most critical flying maneuvers. Here we implement a recently-discovered insect visual-guided landing strategy in which the divergen...
Journal of pharmacokinetics and pharmacodynamics
May 5, 2025
Two recent papers offer contrasting perspectives on integrating Quantitative Systems Pharmacology (QSP) and Artificial Intelligence/Machine Learning (AI/ML): one views QSP as the primary driver using AI/ML to enhance computational tasks, while the ot...
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