AIMC Topic: Models, Biological

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Establishment of a prognostic model based on ER stress-related cell death genes and proposing a novel combination therapy in acute myeloid leukemia.

Journal of translational medicine
BACKGROUND: Acute myeloid leukemia (AML) is a highly heterogeneous malignancy, presenting significant challenges in accurately predicting patient prognosis. Dysregulation of endoplasmic reticulum (ER) stress and resistance to programmed cell death (P...

Gene expression and agent-based modeling improve precision prognosis in breast cancer.

Scientific reports
Breast cancer survival is hard to predict because of the complex ways genes and cells interact. This study offers a new method to improve these predictions by combining gene expression profiling (GEP) with agent-based modeling (ABM). First, GEP will ...

Amphibious robotic dog: design, paddling gait planning, and experimental characterization.

Bioinspiration & biomimetics
Mammal-inspired quadruped robots excel in traversing diverse terrestrial terrains but often lack aquatic mobility, limiting their effectiveness in amphibious environments. To address this challenge, an amphibious robotic dog (ARD) was developed, inte...

Computational modelling of biological systems now and then: revisiting tools and visions from the beginning of the century.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Since the turn of the millennium, computational modelling of biological systems has evolved remarkably and sees matured use spanning basic and clinical research. While the topic of the peri-millennial debate about the virtues and limitations of 'redu...

Exploring the evolutionary adaptations of the unique seahorse tail's muscle architecture through modelling and robotic prototyping.

Journal of the Royal Society, Interface
Seahorses possess a unique tail muscle architecture that enables efficient grasping and anchoring onto objects. This prehensile ability is crucial for their survival, as it allows them to resist currents, cling to mates during reproduction and remain...

Swimming in the "Matrix": VR fish pass the Turing test using a simple control law for collective behavior.

Science robotics
Immersive virtual reality reveals that a simple control model from fish schooling can be used to control autonomous vehicles.

Dynamic simulation of knee joint mechanics: individualized multi-moment finite element modelling of patellar tendon stress during landing.

Journal of biomechanics
Patellar tendinopathy is prevalent in sports requiring high jumping demands, and understanding the in vivo biomechanical behavior of the patellar tendon (PT) during landing is crucial for developing effective injury prevention and rehabilitation stra...

Reversible kink instability drives ultrafast jumping in nematodes and soft robots.

Science robotics
Entomopathogenic nematodes (EPNs) exhibit a bending-elastic instability, or kink, before becoming airborne, a feature previously hypothesized but not substantiated to enhance jumping performance. Here, we provide the evidence that this kink is crucia...

Learning Chemotherapy Drug Action via Universal Physics-Informed Neural Networks.

Pharmaceutical research
OBJECTIVE: Quantitative systems pharmacology (QSP) is widely used to assess drug effects and toxicity before the drug goes to clinical trial. However, significant manual distillation of the literature is needed in order to construct a QSP model. Para...

Sticking the landing: Insect-inspired strategies for safely landing flapping-wing aerial microrobots.

Science robotics
For flying insects, the transition from flight to surface locomotion requires effective touchdown maneuvers that allow stable landings on a variety of surfaces. Landing behaviors of insects are diverse, with some using more controlled flight approach...