Characteristics of individuals in a population, such as age and size, play a key role in determining how populations change over time. In contexts of population dynamics, identifying effective model features, such as fecundity and mortality rates, is...
Agent-based modeling (ABM) is a powerful computational approach for studying complex biological and biomedical systems, yet its widespread use remains limited by significant computational demands. As models become increasingly sophisticated, the numb...
Traditional locomotion strategies fail in low-Reynolds-number fluid environments, where viscous forces dominate over inertial forces. Microorganisms have developed specialized structures such as cilia and flagella to overcome this challenge, enabling...
Latch-mediated spring actuation systems leverage the interplay of springs and latches to rapidly accelerate a load. In biological systems, elastic energy is often distributed across multiple structures, resulting in forces applied from multiple sprin...
This study develops a discrete-time predator-prey model for guava pest management using the piecewise constant argument (PCA) scheme. The model incorporates logistic prey growth, neem-induced mortality, and predator crowding. Analytical and numerical...
BACKGROUND: Quantitative kinetic models of biological regulatory processes play an important role in understanding disease mechanisms. However, their simulation and analysis require specialized domain expertise.
Understanding a drug's plasma half-life is essential in guiding dosage regimens and optimizing therapeutic outcomes, particularly in the early stages of drug development. By using published pharmacokinetic data from Food Animal Residue Avoidance Data...
Model-informed drug development (MIDD) plays an important role in pharmacometrics by leveraging mathematical models to optimize drug dosing strategies. Traditional methods such as nonlinear mixed effects modeling (NONMEM) have long been the gold stan...
Bacteria utilize cell-cell signaling to coordinate gene expression in populations of cells. Bacterial signal exchange was originally interpreted as a mechanism bacteria use to regulate gene expression in response to changes in cell density, denoted a...
Journal of controlled release : official journal of the Controlled Release Society
Nov 17, 2025
Long-acting injectables (LAIs) represent promising drug delivery platforms for chronic diseases management, but their clinical translation remains constrained by extremely long trial-and-error experiments (8-10 years), limited mechanism insights, and...
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