Clinical pharmacology and therapeutics
Apr 19, 2021
Torsade de Pointes (TdP), a rare but lethal ventricular arrhythmia, is a toxic side effect of many drugs. To assess TdP risk, safety regulatory guidelines require quantification of hERG channel block in vitro and QT interval prolongation in vivo for ...
Expert review of clinical pharmacology
Apr 9, 2021
OBJECTIVES: Despite therapeutic vancomycin is regularly monitored, its dose requirements vary considerably between individuals. Various innovative vancomycin dosing strategies have been developed for dose optimization; however, the utilization of ind...
Consumer groups are pressuring modern farmers to be more efficient with a focus on better animal welfare. Herding risks farmer lives, involves stress from farm dogs, and if not performed often and intelligently, risks neglect. We examined the behavio...
Clinical pharmacology and therapeutics
Apr 6, 2021
Therapeutic drug monitoring of mycophenolic acid (MPA) based on area under the curve (AUC) is well-established and machine learning (ML) approaches could help to estimate AUC. The aim of this work is to estimate the AUC of MPA in organ transplant pat...
Multiple sclerosis (MS) can be divided into four phenotypes based on clinical evolution. The pathophysiological boundaries of these phenotypes are unclear, limiting treatment stratification. Machine learning can identify groups with similar features ...
Computer methods in biomechanics and biomedical engineering
Mar 31, 2021
Studies on the deformation characteristics and stress distribution in loaded skeletal muscles are of increasing importance. Reliable prediction of hyperelastic material parameters requires an inverse process, which possesses challenges. This work pro...
We previously demonstrated that Machine learning (ML) algorithms can accurately estimate drug area under the curve (AUC) of tacrolimus or mycophenolate mofetil (MMF) based on limited information, as well as or even better than maximum a posteriori Ba...
PURPOSE: To develop and evaluate a model for obstructive sleep apnea (OSA) detection using an artificial neural network (ANN) based on the combined features of body mass index (BMI), electrocardiogram (ECG), and pulse oxygen saturation (SpO2).
Tolerance to stress conditions is vital for organismal survival, including bacteria under specific environmental conditions, antibiotics, and other perturbations. Some studies have described common modulation and shared genes during stress response t...
is a Gram-negative bacillus included among the six "ESKAPE" microbial species with an outstanding ability to "escape" currently used antibiotics and developing new antibiotics against it is of the highest priority. Whereas minimum inhibitory concent...
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