AIMC Topic: Mutagens
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Machine Learning Techniques for Classifying the Mutagenic Origins of Point Mutations.
Genetics
Mar 19, 2020
There is increasing interest in developing diagnostics that discriminate individual mutagenic mechanisms in a range of applications that include identifying population-specific mutagenesis and resolving distinct mutation signatures in cancer samples....
LightGBM: An Effective and Scalable Algorithm for Prediction of Chemical Toxicity-Application to the Tox21 and Mutagenicity Data Sets.
Journal of chemical information and modeling
Oct 9, 2019
Machine learning algorithms have attained widespread use in assessing the potential toxicities of pharmaceuticals and industrial chemicals because of their faster speed and lower cost compared to experimental bioassays. Gradient boosting is an effect...
Evaluating genotoxicity of metal oxide nanoparticles: Application of advanced supervised and unsupervised machine learning techniques.
Ecotoxicology and environmental safety
Sep 30, 2019
Presence of missing data points in datasets is among main challenges in handling the toxicological data for nanomaterials. As the processing of missing data is an important part of data analysis, we have introduced a read-across approach that uses a ...
Could deep learning in neural networks improve the QSAR models?
SAR and QSAR in environmental research
Aug 28, 2019
Assessing chemical toxicity is a multidisciplinary process, traditionally involving in vivo, in vitro and in silico tests. Currently, toxicological goal is to reduce new tests on chemicals, exploiting all information yet available. Recent advancement...
Development and validation of a sensitive method for alkyl sulfonate genotoxic impurities determination in drug substances using gas chromatography coupled to triple quadrupole mass spectrometry.
Journal of pharmaceutical and biomedical analysis
Dec 30, 2018
Alkyl sulfonate esters have been widely concerned as genotoxic impurities (GTIs). A gas chromatography triple-quadrupole mass spectrometry (GC-MS/MS) method has been developed for trace determination of 9 commonly encountered sulfonate esters in drug...
Manganese oxide nanoparticles induce genotoxicity and DNA hypomethylation in the moss Physcomitrella patens.
Mutation research. Genetic toxicology and environmental mutagenesis
Dec 18, 2018
The genotoxicity of nanoparticles is a major concern for nano-safety appraisal in the bryophytes as they are the primary colonizers of bare land, indicators of atmospheric pollution and excellent accumulators of trace metals. The present study for th...
Effect of inter-individual variability in human liver cytochrome P450 isozymes on cyclophosphamide-induced micronucleus formation.
Mutation research. Genetic toxicology and environmental mutagenesis
Dec 5, 2018
We investigated the relationship between metabolic activities of cytochrome P450 (CYP) isozymes present in microsomal fractions derived from the livers of 78 donors and micronucleus induction by cyclophosphamide (CPA). Consequently, a wide inter-indi...
Investigation of genotoxic effects of paraben in cultured human lymphocytes.
Drug and chemical toxicology
Dec 27, 2017
Paraben is a phenolic derivative of benzoic acid extensively used as preservatives in food, pharmaceutical, and cosmetic industries due to its antimicrobial characteristics. The objective of this study was to evaluate the in vitro genotoxic effects o...
Chemical characterization, antioxidant, genotoxic and in vitro cytotoxic activity assessment of Juniperus communis var. saxatilis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Dec 26, 2017
Chemical composition and antioxidative, genotoxic and cytotoxic potential of essential oil (EO) and post-distillation waste (PDW) of Serbian Juniperus communis L. var. saxatilis Pall. was studied in human lung carcinoma (A549) and normal lung fibrobl...
Cell Line, Tumor
Antioxidants
Plant Extracts
G2 Phase
Cell Line
Female
Rats
Juniperus
Antineoplastic Agents, Phytogenic
Gas Chromatography-Mass Spectrometry
Animals
Apoptosis
Male
Chromatography, Liquid
Mutagens
Doxorubicin
Humans
Drug Screening Assays, Antitumor
Cell Division
Tandem Mass Spectrometry
In silico toxicity profiling of natural product compound libraries from African flora with anti-malarial and anti-HIV properties.
Computational biology and chemistry
Dec 6, 2017
This paper describes an analysis of the diversity and chemical toxicity assessment of three chemical libraries of compounds from African flora (the p-ANAPL, AfroMalariaDb, and Afro-HIV), respectively containing compounds exhibiting activities against...
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