Preoperative classification of brain tumors is critical to developing personalized treatment plans, however existing classification methods rely on manual intervention and often have problems with efficiency and accuracy, which may lead to misdiagnos...
Zhongguo fei ai za zhi = Chinese journal of lung cancer
40114487
BACKGROUND: Epidermal growth factor receptor (EGFR) sensitive mutation is one of the effective targets of targeted therapy for non-small cell lung cancer (NSCLC). However, due to the difficulty of obtaining some primary tissues and the economic facto...
International journal of medical informatics
40157244
BACKGROUND: In Pancreatic Ductal Adenocarcinoma (PDAC), current prognostic scores are unable to fully capture the biological heterogeneity of the disease. While some approaches investigating the role of multi-omics in PDAC are emerging, the analysis ...
Somatic mutations could influence critical cellular processes, leading to uncontrolled cell growth and tumor formation. Understanding the intricate interactions between somatic mutations and drugs was crucial for advancing our knowledge of the underl...
New solutions are needed to detect genotype-phenotype associations involved in microbial drug resistance. Herein, we describe a Group Association Model (GAM) that accurately identifies genetic variants linked to drug resistance and mitigates false-po...
Colorectal cancer (CRC) is a prevalent gastrointestinal tumor worldwide with high morbidity and mortality. Predicting the survival of CRC patients not only enhances understanding of their life expectancies but also aids clinicians in making informed ...
Anti-angiogenic (AA) therapy is a cornerstone of metastatic clear cell renal cell carcinoma (ccRCC) treatment, but not everyone responds, and predictive biomarkers are lacking. CD31, a marker of vasculature, is insufficient, and the Angioscore, an RN...
BACKGROUND: A significant challenge in precision medicine is confidently identifying mutations detected in sequencing processes that play roles in disease treatment or diagnosis. Furthermore, the lack of representativeness of single nucleotide varian...
BACKGROUND: Melanoma (SKCM) is an extremely aggressive form of cancer, characterized by high mortality rates, frequent metastasis, and limited treatment options. Our study aims to identify key target genes and enhance the diagnostic accuracy of melan...