AIMC Topic: Myocytes, Cardiac
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Differential cytotoxicity and internalization of graphene family nanomaterials in myocardial cells.
Materials science & engineering. C, Materials for biological applications
Dec 23, 2016
Given the well-known physical properties of graphene oxide (GO), numerous applications for this novel nanomaterial have been recently envisioned to improve the performance of biomedical devices. However, the toxicological assessment of GO, which stro...
Modeling and analysis of bio-syncretic micro-swimmers for cardiomyocyte-based actuation.
Bioinspiration & biomimetics
Aug 22, 2016
Along with sensation and intelligence, actuation is one of the most important factors in the development of conventional robots. Many novel achievements have been made regarding bio-based actuators to solve the challenges of conventional actuation. H...
Development and characterization of muscle-based actuators for self-stabilizing swimming biorobots.
Lab on a chip
Jul 28, 2016
Biorobots that harness the power generated by living muscle cells have recently gained interest as an alternative to traditional mechanical robots. However, robust and reliable operation of these biorobots still remains a challenge. Toward this end, ...
Drug target identification using network analysis: Taking active components in Sini decoction as an example.
Scientific reports
Apr 20, 2016
Identifying the molecular targets for the beneficial effects of active small-molecule compounds simultaneously is an important and currently unmet challenge. In this study, we firstly proposed network analysis by integrating data from network pharmac...
Nuquantus: Machine learning software for the characterization and quantification of cell nuclei in complex immunofluorescent tissue images.
Scientific reports
Mar 23, 2016
Determination of fundamental mechanisms of disease often hinges on histopathology visualization and quantitative image analysis. Currently, the analysis of multi-channel fluorescence tissue images is primarily achieved by manual measurements of tissu...
Perfluorooctanoic acid-induced toxicity in primary cultures of chicken embryo cardiomyocytes.
Environmental toxicology
Jun 22, 2015
Perfluorooctanoic acid (PFOA) is a widespread environmental contaminant that induces developmental cardiotoxicity. It is detectable in late stage chicken embryos and hatchling chickens. To investigate mechanism(s) of cardiotoxicity, primary cultures ...
Robotic adherent cell injection for characterizing cell-cell communication.
IEEE transactions on bio-medical engineering
Jul 24, 2014
Compared to robotic injection of suspended cells (e.g., embryos and oocytes), fewer attempts were made to automate the injection of adherent cells (e.g., cancer cells and cardiomyocytes) due to their smaller size, highly irregular morphology, small t...
AI-guided laser purification of human iPSC-derived cardiomyocytes for next-generation cardiac cell manufacturing.
Communications biology
May 13, 2025
Current methods for producing cardiomyocytes from human induced pluripotent stem cells (hiPSCs) using 2D monolayer differentiation are often hampered by batch-to-batch variability and inefficient purification processes. Here, we introduce CM-AI, a no...
Identification of key genes and immune infiltration mechanisms in limb ischemia-reperfusion injury: a bioinformatics and experimental study.
Frontiers in immunology
Jan 1, 2025
AIM OF THE STUDY: To establish a cross-tissue bioinformatics model for identifying conserved key genes and immune infiltration mechanisms in ischemia-reperfusion injury (IRI) with experimental validation in limb IRI, including pharmacological targeti...
Classifying Microscopic Acute and Old Myocardial Infarction Using Convolutional Neural Networks.
The American journal of forensic medicine and pathology
Sep 1, 2021
Convolutional neural network (CNN) has advanced in recent years and translated from research into medical practice, most notably in clinical radiology and histopathology. Research on CNNs in forensic/postmortem pathology is almost exclusive to postmo...
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