AIMC Topic: Myocytes, Cardiac
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Cardiac Muscle Cell-based Actuator and Self-stabilizing Biorobot - Part 2.
Journal of visualized experiments : JoVE
May 9, 2017
In recent years, hybrid devices that consist of a living cell or tissue component integrated with a synthetic mechanical backbone have been developed. These devices, called biorobots, are powered solely by the force generated from the contractile act...
Thin polymeric films for building biohybrid microrobots.
Bioinspiration & biomimetics
Mar 6, 2017
This paper aims to describe the disruptive potential that polymeric thin films have in the field of biohybrid devices and to review the recent efforts in this area. Thin (thickness < 1 mm) and ultra-thin (thickness < 1 µm) matrices possess a seri...
Differential cytotoxicity and internalization of graphene family nanomaterials in myocardial cells.
Materials science & engineering. C, Materials for biological applications
Dec 23, 2016
Given the well-known physical properties of graphene oxide (GO), numerous applications for this novel nanomaterial have been recently envisioned to improve the performance of biomedical devices. However, the toxicological assessment of GO, which stro...
Modeling and analysis of bio-syncretic micro-swimmers for cardiomyocyte-based actuation.
Bioinspiration & biomimetics
Aug 22, 2016
Along with sensation and intelligence, actuation is one of the most important factors in the development of conventional robots. Many novel achievements have been made regarding bio-based actuators to solve the challenges of conventional actuation. H...
Development and characterization of muscle-based actuators for self-stabilizing swimming biorobots.
Lab on a chip
Jul 28, 2016
Biorobots that harness the power generated by living muscle cells have recently gained interest as an alternative to traditional mechanical robots. However, robust and reliable operation of these biorobots still remains a challenge. Toward this end, ...
Drug target identification using network analysis: Taking active components in Sini decoction as an example.
Scientific reports
Apr 20, 2016
Identifying the molecular targets for the beneficial effects of active small-molecule compounds simultaneously is an important and currently unmet challenge. In this study, we firstly proposed network analysis by integrating data from network pharmac...
Nuquantus: Machine learning software for the characterization and quantification of cell nuclei in complex immunofluorescent tissue images.
Scientific reports
Mar 23, 2016
Determination of fundamental mechanisms of disease often hinges on histopathology visualization and quantitative image analysis. Currently, the analysis of multi-channel fluorescence tissue images is primarily achieved by manual measurements of tissu...
Perfluorooctanoic acid-induced toxicity in primary cultures of chicken embryo cardiomyocytes.
Environmental toxicology
Jun 22, 2015
Perfluorooctanoic acid (PFOA) is a widespread environmental contaminant that induces developmental cardiotoxicity. It is detectable in late stage chicken embryos and hatchling chickens. To investigate mechanism(s) of cardiotoxicity, primary cultures ...
Robotic adherent cell injection for characterizing cell-cell communication.
IEEE transactions on bio-medical engineering
Jul 24, 2014
Compared to robotic injection of suspended cells (e.g., embryos and oocytes), fewer attempts were made to automate the injection of adherent cells (e.g., cancer cells and cardiomyocytes) due to their smaller size, highly irregular morphology, small t...
Mechanically Matched Heart-on-a-Chip Platform Mediated Maturation of Excitation-Contraction Coupling.
ACS nano
Jul 8, 2025
Heart-on-a-chip (HOC) platforms play a pivotal role in cardiac research, yet existing models suffer from mechanical mismatch between the soft myocardial tissue, sensors, and substrate, leading to impaired myocardial function and compromised data capt...
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